Application of 1,3-di(4-piperidyl)propane in the Mannich reaction. Synthesis of .beta.-amino ketones

Varma, Rajender S.; Nobles, W. Lewis

doi:10.1021/jm00307a060

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1976

1979

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“…Many other spectrophotometric and TLC methods subsequently were proposed for the determination of sulfonamides in biological fluids (4)(5)(6)(7)(8)(9)(10)(11)(12). GLC of the sulfa drugs also was attempted (13-15).…”

Section: Accepted Formentioning

confidence: 99%

“…Various Mannich bases (0-aminoketones) have antimicrobial activity (1)(2)(3)(4); reduction of the keto group in this series of compounds to the corresponding alcohol has been accompanied by an increase in pharmacological activity (5). The bioactivities of such alcohols may be improved by esterification, thereby masking the polar hydroxyl group @CH,FCH, and, consequently, facilitating transportation to a site of action.…”

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confidence: 99%

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