Application of 18F-NaF-PET/CT in assessing age-related changes in the cervical spine

Park, Peter Sang Uk; Raynor, William; Khurana, Navpreet; Sun, Yusha; Werner, Thomas; Høilund‐Carlsen, Poul Flemming; Alavi, Abass; Revheim, Mona‐Elisabeth

doi:10.21037/qims-21-1174

Cited by 4 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NaF uptake has been shown to increase with age in the cervical spine, which may reflect NaF uptake from osteoarthritic structures that are primarily osteoblastic. 21 In contrast, Win and Aparici 22 found no correlation between NaF uptake in the L2 spine and age whereas Kurata et al 23 found a significant negative correlation between NaF uptake in the L3 vertebral body and age in pre/postmenopausal women. Such apparent inconsistency within the literature may reflect that NaF uptake is influenced by both the region of the bone analyzed and the method of analysis.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies have shown mixed results regarding the association between age that NaF uptake with various regions of the body being analyzed. NaF uptake has been shown to increase with age in the cervical spine, which may reflect NaF uptake from osteoarthritic structures that are primarily osteoblastic 21 . In contrast, Win and Aparici 22 found no correlation between NaF uptake in the L2 spine and age whereas Kurata et al 23 found a significant negative correlation between NaF uptake in the L3 vertebral body and age in pre/postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Utility of 18F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine

Park

Resto

Khurana

et al. 2023

Spine

Self Cite

View full text Add to dashboard Cite

Study Design. Cross-sectional; observational. Objectives. To determine whether sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) can be used to monitor decreased bone turnover with aging in the spine. Background. Osteoporosis is characterized by structural changes in the bone such as decreased bone mineral density leading to an increased risk for fractures. An imaging modality capable of identifying molecular changes that precede these structural changes could be critical for the early diagnosis and monitoring of osteoporosis and other metabolic bone disorders. Materials and Methods. The potential of 18F-sodium fluoride (NaF)–PET/CT in detecting changes in bone turnover associated with aging was examined in the lumbar spine of 88 healthy volunteers (43 females, 45 males; mean age 44.6 yr). Regions of interest equal to the trabecular body of the L1 to L4 vertebrae were used to calculate the mean standardized uptake value (SUVmean) and average Hounsfield unit (HU) values. Receiver-operating characteristic curve analysis with an area under the curve using the Wilson/Brown method was generated to assess the value of NaF uptake (SUVmean) in predicting osteoporosis as defined by HU-threshold values. To determine the correlation among global SUVmean, mean HU values, and age, the Spearman correlation test was performed on images acquired at 90 minutes postinjection. Results. There was a significant negative correlation between NaF SUVmean and age in females (P < 0.0001, r = −0.59), and a weaker, but also significant correlation in males (P = 0.03, r = −0.32). In females only, there was a significant correlation between NaF uptake and age at all acquisition time points. Measured NaF uptake increased by 10% to 15% with acquisition time in both sexes, from 45 to 90 minutes and from 90 to 180 minutes. Conclusions. NaF-PET/CT detects decreased vertebral bone turnover with aging, particularly in females. Measured NaF uptake increased with PET acquisition time after tracer injection, which must be considered in follow-up studies monitoring disease development and treatment effects.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The Utility of 18F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine

Park

Resto

Khurana

et al. 2023

Spine

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, quercetin and kaempferol were found to significantly increase COX-2 gene expression, while the former also showed significant upregulation of IL-1β gene expression in osteoblasts. 39,40 In addition, luteolin and quercetin can restrict the messenger RNA (mRNA) expression of MMP-9 and MMP-13 in osteoblasts, safeguarding their inhibitory effects. 41 Mechanistically, tanshinone IIA, the key active ingredient in SYMGD, inhibited the RANKL-mediated activation of NF-κB, MAPK, and Akt signaling pathways during osteoclastogenesis.…”

Section: Discussionmentioning

confidence: 99%

To Explore the Herbal Combinations and Pharmacological Mechanisms of Yourong Huang in the Treatment of Cervical Spondylosis Based on Data Mining and Network Pharmacology

Chai

Huang

Han

et al. 2023

Natural Product Communications

View full text Add to dashboard Cite

Objective: Yourong Huang's drug administration pattern in treating cervical spondylosis (CS) was discussed and evaluated, and the likely mechanism of the high-frequency drug in the treatment of CS to give a reference for the clinical treatment of CS. Materials & methods: The cases of Yourong Huang treating CS were collected, to provide association rules between high-frequency drug pairs, IBM SPSS Statistics 22.0 and IBM SPSS Modeler18.0 were employed. Build a network relationship between “CS core target-active ingredient-drug” was constructed. Results: Two hundred and sixty-two prescriptions were collected, 117 drugs were used, and 2882 doses were taken. Through systematic analysis, the core drug Shaoyao-Mugua Decoction (SYMGD) was discovered. A total of 206 active ingredients were found in the 8 high-frequency prescription drugs. There were 71 potential targets for SYMGD treatment of CS. A total of 158 items were identified by KEGG enrichment analysis, the most important of which were 5 signaling pathways. According to the molecular docking results, SYMGD had good binding activity to its therapeutic targets. Discussion & conclusion: Yourong Huang treated CS with Chinese medicine by “reinforcing liver and kidney, warmly invigorating spleen and stomach, activating blood and resolving stasis.” SYMGD, a core drug group, treats CS through a multicomponent, multitarget, and multipathway comprehensive intervention. Comprehensive analysis calculate the minimum binding energy between 5 key active ingredients and 5 key targets, knowable that SYMGD had good binding activity to its therapeutic target, proving that the prediction of this study was reliable.

show abstract

“…Furthermore, [ 18 F]NaF was initially used solely for detecting bone metastases. However, with advancements in technology and widespread clinical adoption, [ 18 F]NaF has also demonstrated notable accomplishments in the diagnosis and monitoring therapy of bone diseases, cardiovascular conditions, and other fields ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

Zhou,

Liu,

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background As a noninvasive diagnostic tool, fluorine-18-labelled sodium fluoride positron emission tomography ([ 18 F]NaF PET) has been increasingly applied in clinical practice due to its excellent imaging performance, attracting more attention from clinical practitioners. However, with the continuous development of technology and growth of knowledge, the field of [ 18 F]NaF PET is changing. Nevertheless, few studies have conducted quantitative analyses of the literature in this field. Therefore, in this study, we used bibliometric methods to analyze the trends, content distribution, and frontiers of this field from multiple perspectives, including social and international structure, conceptual structure, and intellectual structure. Methods This study used the Web of Science (WOS) core database as the data source and retrieved literature related to [ 18 F]NaF PET between 2008 and 2022. CiteSpace and VOSviewer software were then employed for bibliometric analysis. This study performed co-occurrence analysis and citation analysis to investigate the characteristics of [ 18 F]NaF PET in 3 aspects. Results A total of 682 articles related to [ 18 F]NaF PET were collected during the period from 2008 to 2022. The author, Alavi, had the highest number of publications (67 articles). In terms of institutions, the University of Edinburgh had the highest number of publications (64 articles). The United States (300 articles) was the country with the highest number of published articles. Keyword co-occurrence analysis revealed that [ 18 F]NaF PET-related technologies, bone metastasis (prostate cancer and breast cancer), and atherosclerosis were prominent research directions in this field. In terms of highly cited authors, Even-Sapir had the highest citation count (188 citations). Regarding highly cited journals, the Journal of Nuclear Medicine ranked as the most highly cited journal. The literature co-citation clustering and timeline graph showed that atherosclerotic plaques, bone metastasis, and the clinical applications of [ 18 F]NaF PET were topics of active research in this field. Conclusions There has been an increase in the literature published in the field of [ 18 F]NaF PET from 2008 to 2022. The United States holds a prominent position in the field of [ 18 F]NaF PET. Arteriosclerosis and bone metastasis are the main topics in this field and at the forefront of research.

show abstract

Application of 18F-NaF-PET/CT in assessing age-related changes in the cervical spine

Cited by 4 publications

References 40 publications

The Utility of 18F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine

The Utility of 18F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine

To Explore the Herbal Combinations and Pharmacological Mechanisms of Yourong Huang in the Treatment of Cervical Spondylosis Based on Data Mining and Network Pharmacology

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

Contact Info

Product

Resources

About