Application of 3-methylbenzothiazolin-2-one hydrazone for the quantitative spectrophotometric determination of oxcarbazepine in pharmaceuticals with cerium(IV) and periodate

Rajendraprasad, N.; Basavaiah, K.; Vinay, K. B.

doi:10.1007/s10812-012-9648-5

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Both methods depend on oxidative coupling of analyte with MBTH in the presence of ammonium cerium(IV) sulfate in an acidic medium. The spectrophotometric method involves measuring the absorbance of the stable colored oxidative coupling product , whereas the spectrofluorimetric method measures the quenching effect of the analyte on the fluorescence of Ce 3+ (cerous) .…”

Section: Introductionmentioning

confidence: 99%

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach

et al. 2015

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The aim of this work is to optimize a spectrofluorimetric method for the determination of cefdinir (CFN) using the Taguchi method. The proposed method is based on the oxidative coupling reaction of CFN and cerium(IV) sulfate. The quenching effect of CFN on the fluorescence of the produced cerous ions is measured at an emission wavelength (λ(em)) of 358 nm after excitation (λ(ex)) at 301 nm. The Taguchi orthogonal array L9 (3(4)) was designed to determine the optimum reaction conditions. The results were analyzed using the signal-to-noise (S/N) ratio and analysis of variance (ANOVA). The optimal experimental conditions obtained from this study were 1 mL of 0.2% MBTH, 0.4 mL of 0.25% Ce(IV), a reaction time of 10 min and methanol as the diluting solvent. The calibration plot displayed a good linear relationship over a range of 0.5-10.0 µg/mL. The proposed method was successfully applied to the determination of CFN in bulk powder and pharmaceutical dosage forms. The results are in good agreement with those obtained using the comparison method. Finally, the Taguchi method provided a systematic and efficient methodology for this optimization, with considerably less effort than would be required for other optimizations techniques.

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Section: Introductionmentioning

confidence: 99%

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach

et al. 2015

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“…To date, all analytical methods described in literature for the determination of OXC in pharmaceuticals or in biological and other matrices involve voltammetry [3], chiral liquid chromatography method with ultraviolet detection (LC-UV) [4,5], micellar electrokinetic chromatography [6], microemulsion electrokinetic chromatography [7], HPLC [8][9][10][11][12][13][14][15][16][17][18][19][20], capillary electrophoresis [21], GC-MS [22] and spectrophotometry [23][24][25][26][27][28][29]. The reported methods in the literature suffer from one or the other disadvantage such as poor sensitivity [23][24][25][26]28], scrupulous control of experimental variables, time consuming [27,29], costly reagents [26,29] and uses heating steps [29]. Since, very few methods are reported in the literature and no stability indicating method is available in the official compendia using UV-Spectrophotometry for analyzing of OXC in dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a UV-Spectrophotometric Method for the Quantitative Determination of Oxcarbazepine and Study of its Degradation Profile

Hn¹,

Revanasiddappa²

2014

Chem Sci J

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Oxcarbazepine (OXC) has attracted much attention owing to its multiple health benefits. OXC is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. This study developed and validated a simple, specific, sensitive and reliable stability indicating UV-Spectrophotometric method for the quantitative determination of oxcrbazepine in pure and in pharmaceutical dosage forms. Analysis was performed using methanol: aceonitrile (50:50) as diluents. UV detection was performed at 254 nm. The calibration plot was linear over a concentration range of 0.0-15 µg ml -1 with correlation coefficient values >0.9986. The method was validated for specificity, linearity, precision, accuracy, limit of detection, limit of quantification and robustness. The forced degradation studies were performed by using HCl, NaOH, H 2 O 2 , thermal and UV radiation. Oxcarbazepine is more sensitive towards alkaline conditions and very much resistant towards acidic, oxidative and photolytic degradations. The method was validated as per ICH guidelines. The RSD for intra-and inter-day precision were found to be lesser than 3%. The percentage recovery was in good agreement with the labeled amount in the pharmaceutical formulations and the method is simple, specific, precise and accurate for the determination of oxcarbazepine in pharmaceutical formulations

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Altered electrochemistry of oxcarbazepine on cathodically treated boron-doped diamond electrode: Selective detection by pulsed amperometric detection coupled to flow-injection analysis

Lima¹,

Oliveira

Guedes³

et al. 2018

Electrochimica Acta

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Application of 3-methylbenzothiazolin-2-one hydrazone for the quantitative spectrophotometric determination of oxcarbazepine in pharmaceuticals with cerium(IV) and periodate

Cited by 4 publications

References 26 publications

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach

Development and Validation of a UV-Spectrophotometric Method for the Quantitative Determination of Oxcarbazepine and Study of its Degradation Profile

Altered electrochemistry of oxcarbazepine on cathodically treated boron-doped diamond electrode: Selective detection by pulsed amperometric detection coupled to flow-injection analysis

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