Application of 3D Bioprinting in Urology

Abstract

Tissue engineering is an emerging field to create functional tissue components and whole organs. The structural and functional defects caused by congenital malformation, trauma, inflammation or tumor are still the major clinical challenges facing modern urology, and the current treatment has not achieved the expected results. Recently, 3D bioprinting has gained attention for its ability to create highly specialized tissue models using biological materials, bridging the gap between artificially engineered and natural tissue structures. This paper reviews the research progress, application prospects and current challenges of 3D bioprinting in urology tissue engineering.

Impresión o bioimpresión 3D en el área de la salud. Revisión de la literatura

“…Esta metodología innovadora emplea tintas biológicas y técnicas de impresión para fabricar réplicas de órganos funcionales para pacientes que requieren un trasplante de órganos (26). En esencia, la bioimpresión 3D es una técnica que implica la creación de construcciones tisulares mediante la combinación de células, biotintas y métodos de impresión para imitar la configuración y la funcionalidad de los tejidos humanos (27,28)y, por lo tanto, cerrar la brecha entre las estructuras tisulares sintéticas y naturales (29). Las construcciones tisulares 3D…”

Biomimetic materials to replace tubular tissues

“…As already mentioned, various sources of ECM are decellularized and processed into inks, mainly from porcine tissues 221 . One interesting feature of 3D printing is the possibility to perform dual printing and combine several tissue types, as well as to integrate cells Formulation of dECM bioinks is also investigated for gastrointestinal tract from porcine small intestinal submucosa 222 and urinary tract 223 . To our knowledge, dECM bioinks formulated for vascular tissues are poorly explored 224 -although a few researchers studied the mix of alginate with dECM 225,226 -or rather focused on cardiac tissues 227 .…”

Tissue Engineering and Stem Cell Therapy in Neurogenic Bladder Dysfunction: Current and Future Perspectives

“…Researchers are investigating the use of growth factors and other genes that can stimulate the growth and differentiation of bladder cells [ 27 , 28 ]. 3D printing approaches: These approaches involve the use of 3D printing technology to create custom-made bladder scaffolds that can support the growth and differentiation of cells [ 29 , 30 ]. Neural stem cell transplantation: Neural stem cells can be transplanted into the bladder to generate new nerve cells.…”

“…3D printing approaches: These approaches involve the use of 3D printing technology to create custom-made bladder scaffolds that can support the growth and differentiation of cells [ 29 , 30 ].…”