Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride

Vakili, Hossein; Nyman, Johan; Genina, Natalja; Preis, Maren; Sandler, Niklas

doi:10.1016/j.ijpharm.2016.07.032

Cited by 47 publications

(27 citation statements)

References 23 publications

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“…Vakili et al used near-infrared chemical imaging for content analysis of IJP theophylline using copy paper as the model substrate (10). Researchers from the same group have used a colorimetric technique for content determination of IJP propranolol with colorant added, using edible rice paper and edible icing sheets as the substrates (11) and was also used for quantitative determination of IJP vitamin B2 doses on edible rice paper and copy paper (12). More recently, a handheld near-infrared spectrometer has been reported for API quantification on the IJP dosage forms, containing levothyroxine sodium and prednisolone.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

et al. 2019

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“…Pre-coatings containing high molecular polyethylene glycol aim at a better spreading of hydrophilic fluid on the films [98]. Edible rice paper and icing sheets can be used instead of cast films [104].…”

Section: Pharmaceutical Inkjet Printingmentioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

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“…The use of multiple production sites adds further technical and logistic challenges, wherein it is difficult to ensure that the end-products are of consistent quality, due to the multiple variables affecting the process including different settings, hardware, raw material suppliers and operator training [165]. Thus, this instigates the need for quality control (QC) measurements, such as the use of nondestructive characterization methods, including process analytical technologies (PAT), such as near-infrared (NIR) spectroscopy [166][167][168], Raman spectroscopy [169][170][171] or colorimetry [172,173], to monitor drug performance and ensure requirements imposed by regulatory bodies are being fulfilled.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

3D Printing in Drug Delivery and Biomedical Applications: A State-of-the-Art Review

Mahmood

2021

Compounds

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Personalized medicines are gaining popularity day by day as they empower patient genomics and assist in improved drug design with minimum side effects. Various dosages can be combined into one dose that fits the patient’s requirements. For this purpose, 3D printing is a new technology to produce medicine based on patient needs. It utilizes controlled devices to prepare active pharmaceutical ingredients (API) in a layer-wise fashion to develop an appropriate tailored drug transport structure. It contains numerous methods, including inkjet printing and fused deposition modeling. For this purpose, scientists have used various materials, including polyvinyl alcohol, polylactic acid and polycaprolactone. These materials have been applied to design and develop forms that are suitable for tuning the drug release. Different forms of dosages, including tablets (immediate and pulsatile release) and transdermic dosages, can be produced using the 3D printing technique. Furthermore, the 3D printing technique can also be used to prepare customized medicines to treat life-threatening diseases. In the case of patients needing various medicines, a 3D printer can be used to design and manufacture only one dosage incorporating different medicines. This article reviewed 3D printing utilization for customized medicines based on one’s needs. Various methods and materials used in medicine 3D printing were discussed with their applications.

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Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride

Cited by 47 publications

References 23 publications

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

Oromucosal films: from patient centricity to production by printing techniques

3D Printing in Drug Delivery and Biomedical Applications: A State-of-the-Art Review

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