The development of sustainable trucks has drawn a lot of attention lately. However, the reduction of fuel consumption and emissions related to deep frozen food transports has not yet been satisfactorily considered. In this paper, a thermal Large Eddy Lattice Boltzmann Method (LES-LBM) is applied to investigate two concepts for optimized refrigerated vehicles: (a) the inclusion of vacuum insulation panels (VIP) in the refrigerated body's walls and (b) the introduction of a latent heat storage (LHS) to exchange fuel-driven air conditioning (AC), both with conveniently worth while potential to decrease fuel consumption and related emissions. The present numerical method allows for an accurate and efficient transient conjugate heat transfer simulation including the spatial and temporal resolution of the temperature distribution inside the insulation walls and the cargo in addition to the turbulent surrounding air flow induced by the AC. The present concept of VIP inclusion is found capable of halving the required cooling energy. In addition, it effectively reduces the variations in the temperature of the chilled goods during cooling operation, which is an important measure of the quality of the refrigerated body. The reduced required cooling energy is further found to enable the AC system to be replaced by a LHS mounted near the top of the refrigerator body and an additional ventilation system of lower total capacity. A comparison between simulations with conventional AC and LHS is conducted concerning the temperature homogeneity of loaded deep frozen food products. It is shown that a slight flow around the refrigerated goods is necessary and the maximum downtime of the AC system is 8 min in case of combined PUR and VIP insulation and 11 min in case of an additional LHS.