Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible – A case report

Wongchuensoontorn, Chanchai; Liebehenschel, Niels; Schwarz, Ulrich S.; Schmelzeisen, Rainer; Gutwald, Ralf; Ellis, Edward; Sauerbier, Sebastian

doi:10.1016/j.jcms.2008.11.002

Cited by 44 publications

(32 citation statements)

References 21 publications

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“…In contrast, Coletti and co-workers observed no statistical difference in terms of fracture displacement in a study with an oak bench model when comparing a threaded with a tapered system (Coletti et al, 2007). Locking-plates are often used in reconstructive procedures (Wongchuensoontorn et al, 2009). Kirkpatrick and coworkers showed that locking reconstruction plates facilitate the management of complicated fractures, but postoperative infections cannot be entirely eliminated (Kirkpatrick et al, 2003).…”

Section: Discussionmentioning

confidence: 98%

Clinical aspects of a 2.0-mm locking plate system for mandibular fracture surgery

Sauerbier

Kuenz

Hauptmann

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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SUMMARY. Purpose: The use of a 2.0-mm locking plate system was evaluated in mandibular surgery. Patients and methods: 53 patients (42 male, 11 female) with a total of 56 mandibular fractures were treated with a 2.0-mm mini-locking-plate system and retrospectively examined. Gender, age, cause of fracture, surgical access, classification of fractures, osteosynthesis, postsurgical findings and complications were evaluated. Results: Assault in male patients (mean age 31) was the most common aetiological factor. Fractures in women (mean age 43 years) mostly occurred due to falls. Mandibular angle fractures were the most common and this anatomical site also presented the highest complication rate. Only 6% of patients had minor occlusal disturbance postoperatively, and minor complications (infections and dehiscence) occurred in 14% of patients in this study. Major complications only occurred in one patient included in the study (1.9%). Risk factors for the development of complications in this series were a history of alcohol or tobacco use, mandibular angle fractures, associated facial fractures, presurgical occlusal disturbance and concomitant dental infections. Surgical access to the fracture and the interval from injury to surgery was not associated with the development of complications. Conclusions: The use of a 2.0-mm locking plate system with its advantages of improved handling characteristics, increased stability, shorter surgical time and the preservation of bony perfusion is a viable alternative to conventional miniplates in the management of mandibular fractures. Ó 2010 European Association for Cranio-Maxillo-facial Surgery

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Section: Discussionmentioning

confidence: 98%

Clinical aspects of a 2.0-mm locking plate system for mandibular fracture surgery

Sauerbier

Kuenz

Hauptmann

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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“…This combination has shown efficacy in a wide range of applications, including orthopedic surgery for posterolateral spinal fusion [6,59] or tibial fracture healing [34,41,42]. However, despite these studies demonstrating the effectiveness of this technique, it has rarely been considered for craniofacial bone repair [80,83].…”

Section: Discussionmentioning

confidence: 99%

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

et al. 2015

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“…The FICOLL method might present a useful technique for hospitals; however, the system is a time-consuming one, and a good manufacturing practice (GMP) laboratory is required. To ensure the clinical use in operating facilities without GMP possibilities, closed systems such as closed bone marrow aspirate concentrate (SmartPReP2 Bone Marrow Aspirate Concentrate System; BMAC; Harvest Technologies GmbH) system were developed [38]. Saurbier et al [36] have compared new bone formation in maxillary sinus augmentation procedures using biomaterial associated with MSCs separated by FICOLL and BMAC and observed a higher proportion of hard tissue in the BMAC group.…”

Section: Bone Marrowmentioning

confidence: 99%

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

Ayna¹,

Gülses²,

Wiltfang³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Inadequate bone volume at the implant recipient site presents a clinical challenge for many dental practitioners. To overcome these problems, several approaches have been developed and are currently used, including bone grafting strategies and distraction osteogenesis. Mesenchymal stem cells (MSCs) have gained their popularity within the last two decades, with regard to promising clinical results in improving the bone architecture at the implant recipient site. The aim of this chapter was to briefly outline the accessibility properties, differentiation capacities, isolation, and characterization of MSCs with regard to optimizing bone volume in dental implantology. Additionally, potential benefits and pitfalls are discussed in comparison with the conventional bone augmentation techniques.

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Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible – A case report

Cited by 44 publications

References 21 publications

Clinical aspects of a 2.0-mm locking plate system for mandibular fracture surgery

Clinical aspects of a 2.0-mm locking plate system for mandibular fracture surgery

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

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