The Electric Mopeds (EM) drive system has the characteristics of frequent startup, rapid change of load disturbance and difficulty of establishing accurate mathematical model, this study proposes a modelfree double Fractional-Order integral sliding mode control (DFOISMC). Firstly, a new double Fractional-Order integral sliding mode surface is proposed to enhance the robustness and improve the dynamic response, and to improve flexibility of the conventional integral sliding mode controller (ISMC). Secondly, a super-twisting structure is chosen to suppress chattering phenomenon. Then, the model-free DFOISMC is constructed by utilizing the double Fractional-Order integral sliding mode surface, the super-twisting approach law and the ultra-local dynamic model of EM drive system. Furthermore, the stability of the closed-loop control system under the model-free DFOISMC is proved by the Lyapunov stability theorem. Finally, the digital simulation results demonstrate that the proposed control strategy is highly effective and superior.