Application of a Single-Wall Carbon Nano-Tube Film Electrode to the Determination of Trace Amounts of Folic Acid

Wang, Chenghang; Li, Chunya; Li, Ting; Xu, Xiuling; Wang, Changfa

doi:10.1007/s00604-005-0441-5

Cited by 70 publications

(30 citation statements)

References 18 publications

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“…Analytical methods for folic acid include bioassays [4], enzymatic methods [5], fluorimetry [6][7][8][9][10][11][12][13], spectrophotometry [14][15][16], chromatography [17][18][19][20][21][22][23][24][25], chemiluminescence [26][27][28], phosphorimetry [29] and inductively coupled plasmaatomic emission spectroscopy [30]. Electrochemical methods have been used to detect folic acid [31][32][33][34][35][36][37][38][39][40][41][42] and to investigate its redox properties [43]. Cathodic adsorptive stripping voltammetry has been used previously to detect low levels of folic acid in different electrolytes and electrodes [44 -51].…”

Section: Introductionmentioning

confidence: 99%

Folic acid Determination in neutral pH electrolyte by Adsorptive Stripping Voltammetry at the Mercury Film Electrode

Farias¹

2012

iosrphr

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A stripping method for the determination of folic acid at the submicromolar concentration levels is described. The method is based on controlled adsorptive accumulation of folic acid at the hanging mercury drop electrode followed by differential pulse measurement of the adsorbate. The adsorptive stripping response was evaluated with respect to concentration dependence, accumulation time, accumulation potential, scan-rate, size of the mercury drop, pH, ionic strength, presence of possible interferences and other variables. Cyclic voltammograms at pH 7.1(0.2 mol.L -1 KH 2 PO 4 / NaOH buffer solution) showed four cathodic peaks at -0.57, -0.75, -1.18 and -1.39 V. The second peak, (at -0.75 mV), was the most useful for analytical purposes (more sensitive, quasi reversible and well defined) and it was used for quantifying folic acid by differential pulse adsorptive stripping voltammetry in four types of pharmaceutical multivitamin preparations. Sequential determination of folic acid with ascorbic acid is also possible. The results obtained in analysing medicines having folic acid as active constituent were compared favourably with those obtained by HPLC with UV detection. The average content of folic acid found in these medicines by HPLC was 4.81±0.09mg and by voltammetry, 4.87±0.09mg. The proposed method is very simple, efficient and does not involve time-consuming separation steps.

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Section: Introductionmentioning

confidence: 99%

Folic acid Determination in neutral pH electrolyte by Adsorptive Stripping Voltammetry at the Mercury Film Electrode

Farias¹

2012

iosrphr

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“…The electrochemical behavior of FA has been investigated thoroughly. [20,21] However, its ECL performance has not been studied to date. In our present work, it was found that the electrooxidation of FA in mild acid NaNO 3 solution was accompanied by ECL emission.…”

Section: Folic Acid (Fa) N-[4-[[(2-amino-1 4-dihydro-4-oxo-6-pteridmentioning

confidence: 99%

Determination of folic acid by high‐performance liquid chromatography with direct electrogenerated chemiluminescence reaction

Sun

Zhang

et al. 2009

Luminescence

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In our present work, it was found that the electrooxidation of folic acid (FA) was accompanied by electrogenerated chemiluminescence (ECL) emission. Out of the four inorganic salts, NaNO(3) solution was found to be a suitable supporting electrolyte for the ECL emission of FA. Coupled with high-performance liquid chromatography separation, this simple ECL method was used for post-column determination of FA. Under the optimal conditions, the ECL intensity has a linear relationship with the concentration of FA in the range of 1.0 x 10(-7) to 1.0 x 10(-5) g/mL and the detection limit was 5 x 10(-8) g/mL (signal-to-noise ratio = 3). Application of the present method to the analysis of FA in human urine proved feasible.

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“…Electrochemical methods have also been used and attracted enormous interest due to its advantages of simplicity, rapid response, excellent reproducibility, good stability, low cost and low detection limit, etc. [26][27][28].…”

Section: Introductionmentioning

confidence: 98%

Voltammetric sensor based on ordered mesoporous carbon for folic acid determination

Yang

et al. 2011

Journal of Electroanalytical Chemistry

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Application of a Single-Wall Carbon Nano-Tube Film Electrode to the Determination of Trace Amounts of Folic Acid

Cited by 70 publications

References 18 publications

Folic acid Determination in neutral pH electrolyte by Adsorptive Stripping Voltammetry at the Mercury Film Electrode

Folic acid Determination in neutral pH electrolyte by Adsorptive Stripping Voltammetry at the Mercury Film Electrode

Determination of folic acid by high‐performance liquid chromatography with direct electrogenerated chemiluminescence reaction

Voltammetric sensor based on ordered mesoporous carbon for folic acid determination

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