Application of Alginate Gel as a Vehicle for Liposomes. II. Erosion of Alginate Gel Beads and the Release of Loaded Liposomes.

Takagi, Isamu; Nakashima, Harumi; Takagi, Makiko; Yotsuyanagi, Toshihisa; Ikeda, Ken

doi:10.1248/cpb.45.389

Cited by 14 publications

(5 citation statements)

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“…As the concentration of biopolymer increased, the drug release was significantly reduced due to increased polymer interaction on the surface of particles. However, the release kinetics depends not only on the degradation rate of particles, but also on swelling and erosion of polymer . Moreover, destabilization of chitosan‐ and pectin‐modified particles occurred when too much or little polymer was adding due to depletion flocculation and bridging flocculation and resulted in rapid sedimentation.…”

Section: Discussionmentioning

confidence: 99%

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

et al. 2014

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Bioadhesive liposomes and solid lipid particles (SLPs) modified by pectin and chitosan for oral administration of bovine lactoferrin (bLf) were prepared using a 2(4) full-factorial design to identify the key formulation variables influencing particle size and drug entrapment efficiency (EE). Netlike structures of the polymer-particle mixture consisting of a polymeric network in which multiple particles were imbedded were observed by scanning electron microscopy (SEM). Chemical stability of bLf after encapsulation into pectin- and chitosan-modified liposomes and SLPs was confirmed by Fourier transform infrared spectra (FTIR). Bovine lactoferrin was located within phospholipid bilayer, whereas in SLPs bLf was within the matrix. The crystalline nature of bLf after encapsulation was investigated by differential scanning calorimetry (DSC) of drug-loaded particles, indicating amorphous dispersion of bLf in the polymer-lipid matrix of pectin- and chitosan-modified liposomes and SLPs. In vivo pharmacokinetic investigation of bLf in pectin- and chitosan-modified liposomes and SLPs showed prolonged mean residence time (MRT) of bLf in rat blood and increased the relative bioavailability (Fbio %) by 1.95- to 2.69-fold compared with free bLf. The developed carrier systems are considered to be promising vehicles for oral delivery.

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Section: Discussionmentioning

confidence: 99%

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

et al. 2014

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“…Formulation, characterization, and specific performance of various gel and hydrogel systems are very important topics of investigation in various fields of research. In this sense, gels can be used as stabilizers of various systems, − slow down dynamics of the systems, , can facilitate sustained or controlled release of various functional molecules, − lead to some other specifically desired properties of the systems, − or be simply used to yield the final product solid-like and in this way facilitate its handling. − In this way, such gels are of special importance in the field of pharmaceutical, cosmetics, and food applications. Our interest lies in the polysaccharides methylcellulose (MC; E461) and κ-carrageenan (KC; E407) that are well-known additives used for gelation in various nutrition and other products.…”

Section: Introductionmentioning

confidence: 99%

Internally Self-Assembled Thermoreversible Gelling Emulsions: ISAsomes in Methylcellulose, κ-Carrageenan, and Mixed Hydrogels

et al. 2009

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Self-assembled thermo-gelling emulsions were developed by blending internally self-assembled particles (ISAsomes) with thermoreversible polysaccharide hydrogels of methylcellulose (MC), kappa-carrageenan (KC), and their 1:1 mixture. In this way, the hierarchical structure of ISAsome samples was successfully promoted. The gelified polymer network corresponds to the highest level of the hierarchical structure and as such represents the capturing matrix for the medium structural level, i.e., dispersed emulsion particles, which are further internally structured as the lowest level of structure. Utilizing small-angle X-ray scattering, differential scanning calorimetry, dynamic light scattering, and oscillatory rheological experiments in the temperature regime from 20 to 70 degrees C, we were able to show that the ISAsomes stay practically intact during such embedment into a hydrogel matrix retaining its internal self-assembled structure and its functionality. The characteristic sol-gel and gel-sol transition temperatures of the ISAsome-loaded hydrogel samples showed a slight shift in comparison to the unloaded hydrogel samples. Furthermore, we found that MC is actually able to stabilize the ISAsomes at higher temperatures (tests were conducted up to 90 degrees C). Gels made from MC and KC show quite different features in terms of rheology and differential scanning calorimetry. However, the most interesting results were obtained for the ISAsome-loaded MC-KC (1:1) gelifying system, which behaves as a low- and high-temperature gel with a narrow intermediate temperature window where it is a sol. This specific thermal behavior allows for easy temperature tuning of the system's aggregate state as well as the internal self-assembled structure. As such, this system is suggested to be further tested as the potential media for a temperature-controlled burst/sustained release media of various hydrophilic, hydrophobic, or amphiphilic guest functional molecules.

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“…Interestingly, a faster liposome release was observed when using washed gel beads instead of fully-cured beads, showing a proportional relationship between the release and the erosion of the gel at high liposome concentrations. 126 These results suggested that the liposomes were not homogeneous distributed through the gel beads but rather concentrated in the central part. Such dependence between drug release and the erosion of the alginate gel matrix was also observed by Rongqing and co-workers.…”

Section: Alginatementioning

confidence: 97%

Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience

et al. 2016

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Hydrogels are hydrophilic three-dimensional networks with demonstrated potential for medical and pharmaceutical applications. Specifically, biopolymer-based hydrogels offer certain advantages over synthetic polymers in terms of biocompatibility and biodegradability. Because of their inherent properties, hydrogels are able to efficiently encapsulate and liberate in a controlled release manner, different hydrophobic and hydrophilic therapeutic molecules, including nucleic acids, proteins and antibodies. Several strategies have been reported in the literature to minimize the potential burst release of encapsulated drugs, thus preventing their local accumulation and consequent toxic responses. Within this context, liposomes embedded in hydrogels have emerged as an attractive strategy to reduce this undesirable effect. This tutorial review covers a selection of the most promising cationic, neutral and anionic biopolymer-based hydrogels containing liposomes, niosomes or vesicles for drug delivery or tissue engineering applications.

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Application of Alginate Gel as a Vehicle for Liposomes. II. Erosion of Alginate Gel Beads and the Release of Loaded Liposomes.

Cited by 14 publications

References 0 publications

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

Internally Self-Assembled Thermoreversible Gelling Emulsions: ISAsomes in Methylcellulose, κ-Carrageenan, and Mixed Hydrogels

Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience

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