Application of an [18F]Fluorodeoxyglucose-Sensitive Probe for the Intraoperative Detection of Malignancy

A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes

“…Several authors have addressed the use of the highenergy gamma probe for the detection of tumor deposits with FDG during surgery [3][4][5][6]. The purpose of this study was to establish for the first time that the positron-detecting beta probe is able to detect tumor sites with equivalent reliability to that of the more bulky gamma probe, in humans.…”

Development of a tweezers-type coincidence imaging detector

“…For positron-guided surgery [1][2][3], a positron emitter such as FDG can be detected using two methods: by detecting beta particles or by detecting annihilation gamma photons [4]. In either method, it is diffi cult to distinguish the beta particles or gamma photons from the background gamma photons.…”

Performance of beta- and high-energy gamma probes for the detection of cancer tissue in experimental surgical resection beds

“…The resulting 511 keV photons are used for coincidence PET imaging and for identification with a photon-sensitive, high-energy (gamma) probes [7]. Therefore, intraoperative handheld probes that can detect beta particles and gamma rays emitted from the radioactive decay of Fluorine-18 or other positron-emitters have been developed [8][9][10][11][12][13][14][15]. Probe-guided surgery may assist in the identification of tumor deposits that are undetectable by conventional preoperative imaging techniques [16][17][18][19][20][21][22].…”