“…Many industrial processes produce substantial amounts of saline wastewater (Giustinianovich et al, 2018), for which highrate treatment via anaerobic biofilm-based technologies (such as UASB reactors) are the most interesting, because of a successful biomass immobilization and retention (Xiao and Roberts, 2010;Kobayashi et al, 2018). However, high salinity is regarded a stress factor that severely hampers the performance of biological systems, negatively affecting biomass retention (Hemmelmann et al, 2013;Fang et al, 2018). In sludge granulation, granule strength and stability is considerably reduced in presence of high concentrations of Na + , leading to displacement of the bridging Ca 2+ ions within the EPS matrix (Lambert et al, 1975;Bruus et al, 1992;Ismail et al, 2010).…”