Application of antimicrobial drugs in perioperative surgical incision

Xu, Yang; Xiao, Xurao; Wang, Lefeng; Ao, Yue; Song, Yue; Wang, Huabing; Wang, Huanan

doi:10.1186/s12941-018-0254-0

Cited by 15 publications

(11 citation statements)

References 56 publications

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“…If the prophylaxis is started at the wrong time, the patients will have inadequate serum and tissue concentrations of antibiotic at the time of incision and during the surgery. This, in turn, may lead to a greater risk of contamination and SSIs . We found that the correct dose of antibiotic was administered in 59 cases, whereas other patients received fewer doses than recommended.…”

Section: Discussionmentioning

confidence: 85%

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Adherence to American Society of Health‐System Pharmacists guidelines for antibiotic prophylaxis in thoracic surgery: a prospective observational study

Shadmehr

Baniasadi

2019

Pharmacy Practice and Res

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Background Surgical antibiotic prophylaxis (SAP) decreases the incidence of surgical site infections. However, inappropriate use of prophylactic antibiotics may lead to antibiotic resistance, prolonged hospital stay and adverse drug reactions. Aim This prospective study aimed to assess the concordance of prophylactic antibiotic administration for thoracic operations in Iran with American Society of Health‐System Pharmacists (ASHP) guidelines. Methods The appropriateness of SAP administration in 222 thoracic operations was assessed in a respiratory referral centre over a period of 4 months. Demographic, clinical and SAP data were recorded from patient files. ASHP guidelines were used to evaluate the appropriateness of prophylactic antibiotic administration. Results Cefazolin was correctly prescribed for approximately 70% of patients who required antibiotic prophylaxis. SAP was administered at the correct time (within 60 min before surgery) for 71.6% of surgeries. Intraoperative doses were correctly given in 27.7% of prolonged procedures. In 86.7% of surgeries, antibiotic administration was continued for more than 24 h after surgery (based on a physician's opinion or recent microbiological cultures). Conclusion The results suggest a relatively low rate of consistency between SAP administration and ASHP guidelines in Iran. A long duration of antibiotic administration after operations is an important finding, which should be considered and re‐evaluated by thoracic surgeons in Iran.

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Section: Discussionmentioning

confidence: 85%

“…This, in turn, may lead to a greater risk of contamination and SSIs. 20,21 We found that the correct dose of antibiotic was administered in 59 cases, whereas other patients received fewer doses than recommended. This may be due to a lack of awareness of the updated recommendations (e.g.…”

Section: Discussionmentioning

confidence: 89%

Adherence to American Society of Health‐System Pharmacists guidelines for antibiotic prophylaxis in thoracic surgery: a prospective observational study

Shadmehr

Baniasadi

2019

Pharmacy Practice and Res

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“…Many studies had substantiated the same fact. [36][37][38] The percentage of drugs prescribed from non EML was found to be more in dermatology department. This may be due to the fact that wide variety of skin disorders presents to the OPD, which necessitates the use of drugs from non EML also.…”

Section: Discussionmentioning

confidence: 98%

Outpatient prescription audit in a tertiary care hospital at Puducherry

Babu

Maharani

Jafrin

et al. 2019

Int J Basic Clin Pharmacol

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Background: Rational use of medicines promotes good health practices and prevents inappropriate use of medicines, polypharmacy, unnecessary use of antimicrobials, injections, and also encourages use of medicines from essential medicine list and dispensing by generic names. The aim of the study was to analyze the outpatient prescriptions of a tertiary care centre by utilizing World Health Organization (WHO) core drug use prescribing indicators.Methods: A retrospective observational study was conducted in a tertiary care health setup at Puducherry, South India. Outpatient prescriptions from all the major clinical departments were analyzed using WHO prescribing indicators and they were compared with some similar studies.Results: The average number of drugs per prescription was 2.74. The percentage of prescriptions with antibiotics was 20.33% and the percentage of prescriptions with injections was 0.16%. The percentage of drugs prescribed by generic names and from essential medicine list was 83.13% and 87.9 respectively. Further antibiotic utilization was found to be higher in the department of ENT (56.67%), respiratory medicine (45%) and surgery (40%). Percentage of drugs prescribed by generic names in pediatrics and respiratory medicine were found to be 67.88% and 65.27% and percentage of drugs prescribed from essential medicine list in dermatology was 69.62%.Conclusions: Prescription pattern followed in our Institute almost adheres to the guidelines laid down by the WHO. Moreover, it is also implied that a routine audit of this type should be done in health care setups to ensure that they adhere to the WHO guidelines for better health care.

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“…Postoperative infections are a significant source of preventable perioperative morbidity and mortality, being a burden for patients’ quality of life and health care systems [22,23]. Prophylactic antibiotics have been used to prevent nosocomial infections but their effects are often impaired by the development of highly resistance bacterial strains [24,25,26]. To circumvent antibiotic resistance and provide postoperative infection prophylaxis, AgNPs were loaded within the HG as silver ions have strong antimicrobial activity, even against most resistant strains [27,28].…”

Section: Discussionmentioning

confidence: 99%

Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications

et al. 2019

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Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high sensitivity to sterilization processes is however one of the greatest challenges regarding their clinical translation. Concerning infection diseases, prevention of post-operatory related infections is crucial to ensure appropriate patient recovery and good clinical outcomes. Silver nanoparticles (AgNPs) have shown good antimicrobial properties but sustained release at the right place is required. Thus, we produced and characterized thermo-sensitive HG based on Pluronic® F127 loaded with AgNPs (HG-AgNPs) and their integrity and functionality after sterilization by dry-heat and autoclave methods were carefully assessed. The quality attributes of HG-AgNPs were seriously affected by dry-heat methods but not by autoclaving methods, which allowed to ensure the required sterility. Also, direct sterilization of the final HG-AgNPs product proved more effective than of the raw material, allowing simpler production procedures in non-sterile conditions. The mechanical properties were assessed in post mortem rat models and the HG-AgNPs were tested for its antimicrobial properties in vitro using extremely drug-resistant (XDR) clinical strains. The produced HG-AgNPs prove to be versatile, easy produced and cost-effective products, with activity against XDR strains and an adequate gelation time and spreadability features and optimal for in situ biomedical applications.

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Application of antimicrobial drugs in perioperative surgical incision

Cited by 15 publications

References 56 publications

Adherence to American Society of Health‐System Pharmacists guidelines for antibiotic prophylaxis in thoracic surgery: a prospective observational study

Adherence to American Society of Health‐System Pharmacists guidelines for antibiotic prophylaxis in thoracic surgery: a prospective observational study

Outpatient prescription audit in a tertiary care hospital at Puducherry

Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications

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