Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents

Vakili, Bahareh; Jahanian-Najafabadi, Ali

doi:10.1007/s10989-023-10501-w

Cited by 4 publications

(3 citation statements)

References 126 publications

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“…MLT has a cytolytic effect on cancer cells and can kill the cancer cell by creating a pore in the cell membrane. [ 162 ] A label‐free mid‐infrared biosensor was developed which is able to distinguish a wide variety of analytes in heterogenous samples. This sensor has shed light on the interaction of lipid layers with various polypeptides.…”

Section: Anticancer Effect Of Mltmentioning

confidence: 99%

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

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Melittin (MLT), a peptide containing 26 amino acids, is a key constituent of bee venom. It comprises ∼40%–60% of the venom's dry weight and is the main pricing index for bee venom, being the causative factor of pain. The unique properties of MLT extracted from bee venom have made it a very valuable active ingredient in the pharmaceutical industry as this cationic and amphipathic peptide has propitious effects on human health in diverse biological processes. It has the ability to strongly impact the membranes of cells and display hemolytic activity with anticancer characteristics. However, the clinical application of MLT has been limited by its severe hemolytic activity, which poses a challenge for therapeutic use. By employing more efficient mechanisms, such as modifying the MLT sequence, genetic engineering, and nano‐delivery systems, it is anticipated that the limitations posed by MLT can be overcome, thereby enabling its wider application in therapeutic contexts. This review has outlined recent advancements in MLT's nano‐delivery systems and genetically engineered cells expressing MLT and provided an overview of where the MLTMLT's platforms are and where they will go in the future with the challenges ahead. The focus is on exploring how these approaches can overcome the limitations associated with MLT's hemolytic activity and improve its selectivity and efficacy in targeting cancer cells. These advancements hold promise for the creation of innovative and enhanced therapeutic approaches based on MLT for the treatment of cancer.

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Section: Anticancer Effect Of Mltmentioning

confidence: 99%

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

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“…Cecropin interacts with the negatively charged lipids in the cell membrane of bacteria through its N-terminal helix and creates pores in the membrane through its hydrophobic C-terminal helix, disturbing membrane permeability. The wide spectrum anti-bacterial activity of cecropin is attributed to this interaction with membrane lipid bilayers (Vakili and Jahanian, 2023). The membranes of cancer cells differ in lipid composition from normal cells and have an elevated negative charge due to exposure of phosphatidylserine on the outer leaflets of the membranes.…”

Section: Cecropinmentioning

confidence: 99%

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Sinha,

Choudhury

2024

Front. Pharmacol.

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Cancer has been medicine’s most formidable foe for long, and the rising incidence of the disease globally has made effective cancer therapy a significant challenge. Drug discovery is targeted at identifying efficacious compounds with minimal side effects and developments in nanotechnology and immunotherapy have shown promise in the fight against this complicated illness. Since ancient times, insects and insect-derived products have played a significant role in traditional medicine across several communities worldwide. The aim of this study was to inspect the traditional use of edible insects in various cultures and to explore their modern use in cancer therapy. Edible insects are sources of nutrients and a variety of beneficial substances with anticancer and immunomodulatory potential. Recently, insect derived bioactive-components have also been used as nanoparticles either in combination with chemotherapeutics or as a nano-cargo for the enhanced delivery of chemotherapeutic drugs due to their high biocompatibility, low bio-toxicity, and their antioxidant and anticancer effects. The crude extracts of different edible insects and their active components such as sericin, cecropin, solenopsin, melittin, antimicrobial peptides and fibroin produce anti-cancer and immunomodulatory effects by various mechanisms which have been discussed in this review.

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“…57−59 Despite the structural diversity of ACPs/AMPs, they share common structural characteristics that are crucial to their biological functions, including short sequences, positively chargeable amino acid residuals, and amphiphilic feature. 60,61 In our study, an amphipathic motif FIIIKKK was adopted, in which I 3 K 62 has been demonstrated in the literature to form a β-sheet secondary structure and self-assemble into nanofibers, while F helps peptide self-assembly via π−π interactions. The multiple K in the sequence would increase the possibility of interaction with anionic membranes of cancer cells.…”

Section: Preparation and Characterization Of Peptide/mentioning

confidence: 99%

Peptide-Based Double-Network Hydrogels for Melanoma Treatment and Wound Healing Promotion

Hou

Tian

et al. 2023

ACS Appl. Mater. Interfaces

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Although surgery is the primary method to treat malignant melanoma, it has drawbacks such as residual tumor that could trigger cancer recurrence and wound infections that are especially difficult to heal in diabetics. In this research, we have constructed anti-cancer peptides/polyvinyl alcohol (PVA) doublenetwork (DN) hydrogels for the treatment of melanoma. The maximum stress of the DN hydrogels is found to be larger than 2 MPa, which endows the DN hydrogels with ideal mechanical performance for therapeutic wound dressing. The peptides naphthalene-FIIIKKK (IK1) and phloretic acid-FIIIKKK (IK3) that were previously developed as effective antibacterial peptides, as well as the peptide/PVA DN hydrogels, are found to have good anti-cancer efficacy and target mouse melanoma cells B16-F10 while being nontoxic to normal cells. Further studies have revealed that IK1 and IK3 damage the tumor cell membrane and mitochondrial membrane and eventually trigger apoptosis. In the mouse melanoma model and the diabetic bacterial infection model, the DN hydrogels exhibit great anti-tumor, anti-bacterial, and wound healing promotion abilities in vivo. Because of their excellent mechanical properties, the DN hydrogels are promising soft materials for directly treating malignant melanomas as well as for preventing recurrence and bacterial infection after melanoma surgery that promote wound healing.

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Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents

Cited by 4 publications

References 126 publications

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Peptide-Based Double-Network Hydrogels for Melanoma Treatment and Wound Healing Promotion

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