Application of aqueous two-phase systems for the extraction of pharmaceutical compounds from water samples

Assis, Roberta C.; Mageste, Aparecida Barbosa; Lemos, Leandro Rodrigues de; Orlando, Ricardo Mathias; Rodrigues, Guilherme Dias

doi:10.1016/j.molliq.2019.112411

Cited by 25 publications

(17 citation statements)

References 45 publications

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“…ATPS containing biodegradable macromolecule are nontoxic, non-flammable, and inexpensive and can be reused in the separation process, 1 making the technique both economically viable and environmentally acceptable. The outstanding characteristics of these ATPS allow their use to replace traditional liquid−liquid extraction employing toxic and/or volatile organic solvents 2 for the separation/purification of analytes of biological or industrial interest, including pharmaceuticals, 3 proteins, 4 dyes, 5 priority pollutants, 6 cocaine, 7 chemical speciation, 8,9 and metals. 10,11 Aiming to expand the applications of ATPS, new phase equilibrium data have been reported, in most cases for systems produced with poly(ethylene oxide) (PEO).…”

Section: Introductionmentioning

confidence: 99%

Liquid–Liquid Equilibrium Data of Macromolecule + Ammonium Thiosulfate + Water Ternary Systems at 283.2, 298.2, and 313.2 K

et al. 2021

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Liquid−liquid equilibrium data were obtained for aqueous two-phase system (ATPS) composed of [poly(ethylene oxide) (PEO1500), poly(propylene oxide) (PPO425), poly(ethylene oxide) 11 −poly(propylene oxide) 17 −poly(ethylene oxide) 11 (L35), or poly(propylene oxide) 8 −poly(ethylene oxide) 22 −poly(propylene oxide) 8 (10R5)] + ammonium thiosulfate + water, at 283.2, 298.2, and 313.2 K. The consistencies of the all tie-line experimental compositions were improved by applying the Othmer− Tobias and Bancroft equations, resulting in linear correlation coefficients (R 2 ) ≥ 0.95. For all the ATPS, an increase in the temperature resulted in increases in the biphasic region and the tie-line slope, indicating that the phase separation process was entropically driven. Among the macromolecules studied, PPO425 produced the largest biphasic region, due to its greater hydrophobicity, followed by L35 ≈ 10R5 > PEO1500.

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Section: Introductionmentioning

confidence: 99%

Liquid–Liquid Equilibrium Data of Macromolecule + Ammonium Thiosulfate + Water Ternary Systems at 283.2, 298.2, and 313.2 K

et al. 2021

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“…The transfer process of tylosin at the selected temperature was endothermic owing to the positive Δ tr H value. The positive values of Δ tr H and Δ tr S suggested that the partitioning process of tylosin was entropically driven [34].…”

Section: Tylosin Partitionmentioning

confidence: 99%

Effective extraction of tylosin and spiramycin from fermentation broth using thermo‐responsive ethylene oxide/propylene oxide aqueous two‐phase systems

Yang

Zheng

Yan

et al. 2021

J of Separation Science

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Recyclable aqueous two-phase systems with thermo-responsive phase-forming materials have been employed to separate macromolecules; however, these systems have achieved very limited separation efficiency for small molecules, such as antibiotics. In this study, aqueous two-phase systems composed of the ethylene oxide/propylene oxide copolymer and water were developed to extract alkaline antibiotics from the fermentation broth. In the aqueous twophase systems with an ethylene oxide ratio of 20 and propylene oxide ratio of 80, the partition coefficients of tylosin and spiramycin reached 16.87 and 20.39, respectively, while the extraction recoveries were 70.67 and 86.70%, respectively. Coupled with mechanism analysis, we demonstrated the feasibility of extracting alkaline antibiotics using this aqueous two-phase system, especially for 16-membered macrolide antibiotics. The molecular dynamic simulation was employed to visualize the process of dual-phase formation and the partition behavior of antibiotics in an aqueous two-phase system. The dynamic simulation revealed the binding energy between the antibiotic and ethylene oxide/propylene oxide copolymers, which provides a simple indicator for screening suitable antibiotics in aqueous two-phase systems. Our recyclable aqueous two-phase systems provide a robust approach for the extraction of 16-membered macrolide antibiotics with ease of operation and high recovery rates, which is appropriate for large-scale extraction in the fermentation industry.

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“…Aqueous two-phase systems (ATPS) are composed of immiscible two (or more) components in water which are formed when the systems reach equilibrium. ATPS are a novel separation and extraction technology with higher water content, lower interfacial tension, non-toxic, environmentally friendly comparing with traditional liquid-liquid extraction [1][2][3]. It has been extensively studied in the extraction and purification of downstream products, for example, nanoparticles [4], proteins [5], antibiotics [6], biological molecules [7].…”

Section: Introductionmentioning

confidence: 99%

Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

Wei

Chen

Yang

et al. 2021

Appl Biochem Biotechnol

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Aqueous two-phase systems (ATPS) have the advantages of environmentally friendly, high mass transfer efficiency, mild extraction conditions. However, it is difficult to recycle these components, which limits the large-scale application of ATPS in industrial production. In this study, a novel recyclable ATPS of PN/PADB4.78 was constructed with a thermo-responsive polymer PN and a pH-responsive polymer PADB4.78 for the partition study of tea saponin. The recovery of PN reached 98.71% by adjusting the temperature to above its lower critical solution temperature (LCST, 33.0 °C ) and the recovery of PADB4.78 was 97.32% by regulating the pH to its isoelectric point (pI, 4.78). Meanwhile, the phase formation mechanism of ATPS was studied by surface tension and low-field nuclear magnetic resonance (LF-NMR). The effects of polymer concentration, pH, temperature, types and concentrations of salt were investigated on tea saponin partition.In the 1.5% PN/3.5% PADB4.78 ATPS, the optimal partition coefficient (K) and extraction recovery (ERb) of crude tea saponin were 0.15 and 92.13% in the presence of 1.5 mM KCl at pH=7.6 and 25℃, respectively. The K and ERb of tea saponin from tea seeds were 0.12 and 94.50% with 7.5 mM LiBr at pH=8.0 and 25℃, respectively.

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Application of aqueous two-phase systems for the extraction of pharmaceutical compounds from water samples

Cited by 25 publications

References 45 publications

Liquid–Liquid Equilibrium Data of Macromolecule + Ammonium Thiosulfate + Water Ternary Systems at 283.2, 298.2, and 313.2 K

Liquid–Liquid Equilibrium Data of Macromolecule + Ammonium Thiosulfate + Water Ternary Systems at 283.2, 298.2, and 313.2 K

Effective extraction of tylosin and spiramycin from fermentation broth using thermo‐responsive ethylene oxide/propylene oxide aqueous two‐phase systems

Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

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