The influence of braking sequence on railway brake disc's radial crack propagation behavior is analyzed considering the effect of crack geometry features, material elastoplasticity, and crack closure. The results show that when the residual stress generated in the initial braking is low, the peak stress in the subsequent braking will be low, and the average response state is more inclined to compression. The influences of the braking sequence are mainly reflected in the mid‐late stage of crack growth. In the early stage, the radial cracks almost synchronously expand inward and outward. While in the mid‐late stage, the cracks mainly expand inward. When the initial braking is relatively mild, the brake disc's stress–strain response and crack propagation behavior can be improved. It is beneficial to extend the brake disc's service life by designing a suitable prefabricated working condition or introducing an appropriate residual stress field through surface treatment.