Application of Benzoylaceteonitrile in the Synthesis of Pyridines Derivatives

Structural, Electronic and Vibrational Study of 4, 6-Dichloro-5-Methylpyrimidine: A DFT Approach

“…Pyrimidine derivatives containing nitrogen atoms are known for their pharmacological applications. They are used as pesticides, pharmaceutical agents (Condon et al, 1993;Maeno et al, 1990), antiviral agents (Alam et al, 2010), herbicides (Selby et al, 2002), antioxidant and for applications of organoselenide compounds (Khidre et al, 2013).The aim of present study is to investigate the vibrational frequencies of with potential energy distribution 4, 6-dichloro-5-methylpyrimidine (DMP) together with the structural parameters. X-ray diffraction method is one of the most frequently applied techniques for structural characterization of pharmaceutical compounds which is sensible to the long-range order molecules.…”

Chemodivergent, One-Pot, Multi-Component Synthesis of Pyrroles and Tetrahydropyridines under Solvent- and Catalyst-Free Conditions Using the Grinding Method

“…In addition several synthetic tetrahydropyridines have been shown to display important biological activities. On the other hand, 2,3,5-trisubstituted pyrroles have also been studied to exhibit significant biological activities. , The tetrahydropyridines and pyrroles may be synthesized via a number of classical methods that also include the treatment of allylic alcohols with potassium bis­(trimethylsilyl)­amide, − intermolecular amido carbonylation of carbomates, and intramolecular condensations of aldehydes with enamides. Several methods, such as transition metal-catalyzed cycloadditions, coupling of enamides with alkynes, and oxidative cyclization of N -allyamines are available for the syntheses of polysubstituted pyrroles. − However, most of these methods have drawbacks, such as the use of expensive reagents or catalysts, lower yields, and poor selectivity.…”

Fused Imidazopyrazoles: Synthetic Strategies and Medicinal Applications

“…Also, imidazo [1,2-b]pyrazole nucleus used as photographic dye-forming couplers comprise, useful in photographic materials and processes, have improved absorption [16][17][18][19]. In view of the above fact and in connection to our previous review articles about biologically active heterocyclic systems [20][21][22][23][24][25], we decided to prepare this review to present for the reader a survey of the literature of the different azoles linked directly with imidazole nucleus; also some of the medicinal applications are mentioned.…”