Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases

Abstract

Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P2O5-CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals’ quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.

Case Report: First Evidence of a Benign Bone Cyst in an Adult Teckel Dog Treated With Shark Teeth-Derived Bioapatites

“…Other studies have also studied synthetic calcium phosphates in mandibular and appendicular defects. Promising results were obtained in terms of speed of bone healing, reduction of the morbidity and improving the quality life of the patients ( 30 ).…”

Application of Shark Teeth–Derived Bioapatites as a Bone Substitute in Veterinary Orthopedics. Preliminary Clinical Trial in Dogs and Cats

“…Other calcium phosphate ceramics have previously been used as bone substitutes in the veterinary field, obtaining good results in terms of improving the quality of life of the patient, speed of bone healing, and decrease in morbidity. In the mentioned research study (4,48), the effectiveness of the material in appendicular and maxillary/mandibular bone defects was studied. The patients did not present any adverse effects at the local or systemic level, and the functional recovery was good in all cases, as in the present study.…”

“…Moreover, they are used to promote bone regeneration in traumatic tissue damage or injuries (1). In maxillofacial and dental surgery, bone graft scaffolds are commonly used to contribute to the suitable environment for periodontal regeneration and maxillary sinus elevation, to repair defects after teeth extraction and/or in cases of implant placement (2)(3)(4).…”

“…These evidences justify continued sacrifices to develop effective synthetic substitutes for bone grafting. The discovery of calcium phosphate ceramics and other related biomaterials has provided a better control of the resorption process improving the capacity of the materials in the bone regeneration (4).…”

Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone substitute

“…It has been a subject of extensive characterization and clinical evaluation, which provided the conformity of the material for human use [ 23 – 30 ]. Particularly, BL® granules (250 to 500 μm) have been used successfully in maxillofacial surgery to repair bone defects caused by removal of cysts and elevation of the maxillary sinus, resulting in partial regeneration of the bone defect with no adverse reaction [ 30 ], and recently functioned as a space filler in appendicular bone defects and maxillary/mandibular bone defects, promoting a faster bone fusion in 14 animals [ 31 ]. Although currently unavailable, this study intends to accelerate BL® (250 to 500 μm) market re-entry, now as an innovative injectable device.…”