Application of boron-entrapped stealth liposomes to inhibition of growth of tumour cells in the in vivo boron neutron-capture therapy model

Yanagië, Hironobu; Maruyama, Kazuo; Takizawa, Tomoko; Ishida, Osamu; Ogura, Koichi; Matsumoto, Takuya; Sakurai, Yoshinori; Kobayashi, Takao; Shinohara, Atsuko; Rant, J.; Skvarč, J.; Ilić, R.; Kühne, G.; Chiba, Momoko; Furuya, Yoshitaka; Sugiyama, Hirotaka; Hisa, Tomoyuki; Ono, Koji; Kobayashi, Hisao; Eriguchi, Masazumi

doi:10.1016/j.biopha.2005.05.011

Cited by 49 publications

(21 citation statements)

References 26 publications

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“…Application of passive stealth liposome-entrapped 10 B delivery systems has been studied for BNCT in animal models. 132,133 The results of the study on 10 B-PEG-liposome through i.v. injection suggested that passively targeted delivery of sodium mercaptoundecahydrododecaborate can increase the retention of 10 B by tumor cells, causing the suppression of tumor growth in vivo for BNCT.…”

Section: Nuclear Imagingmentioning

confidence: 99%

Nanotargeted Radiopharmaceuticals for Nuclear Imaging and Radiotherapy

Ting¹,

Tseng²,

Chang³

et al. 2014

Frontiers in Nanobiomedical Research

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Nanotechnology holds signifi cant promise for improving the development of new and paradigm shift tools for the targeted personalized diagnostics and therapeutics of cancer and other diseases. Current progress in nanotechnology has exploited the possibility of designing tumor-targeted nanocarriers that can deliver radionuclide payloads in a site or molecular selective manner to improve the effi cacy and safety of nuclear imaging and radiotherapy. Radionuclides of auger electron-, α-, β-, γ-and positronemitters have been after-loaded, inserted and surface bioconjugated in nanoparticles (NPs) to improve the effi cacy and to reduce the toxicity in preclinical studies. In addition, the combining of disease-specifi c multifunctional, multimodality and multivalent delivery of nanocarriers will hopefully achieve earlier disease detection and better treatment.The aim of this chapter is to provide an overview of nanotargeted radionuclides, up-to-date research and development, current status of applications, advantages, problems and future prospects and challenges. Two major strategies of passively and actively nanotargeted radiopharmaceuticals with illustrating examples are briefl y reviewed and summarized. Current advances in research of passive targeting co-delivery of radionuclides and chemotherapeutics, and advantages of nanocarriers in multifunctional and multimodality application for nuclear imaging and radiotherapy are discussed. Finally, radiotoxicology/nanotoxicology, clinical research and regulatory issues are also briefl y explored. Research on the combining different modes of selective delivery of radionuclides with targeted nanocarriers offers the new possibility Handbook of Nanobiomedical Research Downloaded from www.worldscientific.com by UNIVERSITY OF TOKYO on 06/05/15. For personal use only. 78 G. Ting et al. of increasing personalized diagnostic effi cacy and radiotherapeutic index. However, further efforts and challenges in preclinical and clinical effi cacy and toxicity studies are required to translate those advanced new technologies to the clinical applications for the healthcare benefi t of the patients.

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Section: Nuclear Imagingmentioning

confidence: 99%

Nanotargeted Radiopharmaceuticals for Nuclear Imaging and Radiotherapy

Ting¹,

Tseng²,

Chang³

et al. 2014

Frontiers in Nanobiomedical Research

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“…Previously, we represented that liposomes were good drug delivery carriers [3,4]. In addition, we succeeded to prepare the liposomal bubbles (Bubble liposomes) entrapping perfluoropropane which was the gas utilized for contrast enhancement in ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Effective Gene Delivery with Novel Liposomal Bubbles

Nishiie¹,

Suzuki²,

Oda³

et al. 2010

AIP Conference Proceedings

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“…The radiation emitted from this reaction is mainly composed of lithium ions and alpha particles ( 7 Li and a), which are high linear energy transfer (LET) particles with a significant ability to destroy biological molecules (3). These particles have a penetration path length of about 10 um in biological tissues, which is approximately equivalent to one cell diameter (4). Therefore, it is theoretically possible to destroy tumor cells without affecting adjacent healthy cells if a sufficiently high 10 B concentration is selectively delivered to the tumor cells.…”

Section: Introduction 239mentioning

confidence: 99%