Application of Bromocresol Green and Bromothymol Blue for the Extractive Spectrophotometric Determination of Anti-hypertensive Drugs

Abstract

Simple, selective and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of anti-hypertensive drugs namely telmisartan (TEL), propranolol (PRO), bisoprolol (BIS) and carvedilol (CRV) in tablets and biological fluids using bromocressol green (BCG) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored dichloromethane extractable ion-pair complexes of the amino derivative of four antihypertensive drugs such as TEL, PRO, BIS and CRV with two sulphonphthalein acid dyes, namely; BCG and BTB in acidic buffer. The effect of optimum conditions via pH on the ion-pair formation, reagent concentration, time and temperature and solvent was studied. The composition of the ion-pairs was found 1: 1 by Job's method. The established methods having high sensitivity and good selectivity could be applied to the determination of the studied drugs in pharmaceutical, urine and blood serum samples with satisfactory results. The results obtained are good agreement with experimental data. The reaction mechanism was also discussed.

Nanosensors in the detection of antihypertension drugs, a golden step for medication adherence monitoring

“…Highly sensitive, simple, selective and spectrophotometric procedures are planned for the fast and accurate determination of some AHTDs such as bisoprolol (BIS), and telmisartan (TEL), in biological fluids and pills using bromothymol blue (BTB) and bromocressol green (BCG) [ 17 ]. Liquid chromatography–tandem mass spectrometry (LC-TMS) was applied for sensitive determination of antidepressants and anxiolytics and AHTDs.…”

“… Methods Comments and significances Ref SPEC This method showed good selectivity, high sensitivity and could be applied to the determination of the AHTDs in urine, pharmaceutical, and physiological samples with acceptable results. [ 17 , 18 , 19 ] LC-TMS Finding demonstrated the practicality of this method for environmental neurotoxicity trainings. [ 20 ] HPTLC HPTLC method offers a typical simple and reliable chromatographic approach for the routine quality control analysis.…”

Development and validation of spectrophotometric method for quantitative determination of carvedilol in tablets

“…(13). Reaction of ionic associate formation with bromocresol green is the basis of another extraction-photometric method (14). From the literature data analysis, it follows that the existing methods of spectrophotometric determination of carvedilol are not always selective, sensitive, express, and satisfy the provisions of "green chemistry".…”

A Simple and Highly Selective Determination of Telmisartan at Sodium Dodecyl Sulfate Modified Pyrolytic Graphite Surface

“…TMS selectively inhibits the action of angiotensin type I receptor without affecting the action of other receptors in cardiovascular regulation, which leads to reduced blood pressure, and hence the blood flows smoothly. TMS is a potent, long‐term, orally acting non‐peptide antagonist, which is utilized for the management of essential hypertension . The generally effective dose of TMS is 40–80 mg per day and can be increased to a maximum of 80 mg once a day.…”