Application of Calcium Carbonate as a Controlled Release Carrier for Therapeutic Drugs

Li, Siying; Lian, Bin

doi:10.3390/min13091136

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…The loading capacity of these systems depends on several factors, such as the porosity and specific surface area of the CaCO3 particles and the chemical properties of the drug. Studies have shown significant effectiveness of low-molecular-weight drug encapsulation [30] and their controlled release from CaCO3 cores [31], sometimes with a reduced cytotoxicity [32]. The efficiency of encapsulation and stability of encapsulated molecules have been also demonstrated for proteins [33] and nucleic acids [34].…”

Section: A B Cmentioning

confidence: 99%

Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Biny,

Gerasimovich,

Karaulov

et al. 2024

Preprint

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Nano- and microparticles are increasingly widely used in biomedical research and applications, particularly as specific labels and targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it has some disadvantages limiting its potential, such as the proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being easily available, cost-effective, biocompatible material with high porosity and surface reactivity, which makes it an attractive choice for targeted drug delivery. CaCO3 particles are used in this field in the form of either bare CaCO3 microbeads or core/shell microparticles representing polymer-coated CaCO3 cores. In addition, they serve as removable templates for obtaining hollow polymer microcapsules. Each of these types of particles has its specific advantages in terms of biomedical applications. CaCO3 microbeads are primarily used due to their capacity for carrying pharmaceutics, whereas core/shell systems ensure better protection of the drug-loaded core from the environment. Hollow polymer capsules are particularly attractive because they can encapsulate large amounts of pharmaceutical agents and can be so designed as to release their contents in the target site in response to specific stimuli. This review focuses first on the chemistry of the CaCO3 cores, core/shell microbeads, and polymer microcapsules. Then, systems using these structures for the delivery of therapeutic agents, including drugs, proteins, and DNA, are outlined. The results of systematic analysis of available data are presented. They show that the encapsulation of various therapeutic agents in CaCO3-based microbeads or polymer microcapsules is a promising technique of drug delivery, especially in cancer therapy, enhancing drug bioavailability and specific targeting of cancer cells while reducing side effects. To date, research in CaCO3-based microparticles and polymer microcapsules assembled on CaCO3 templates has mainly dealt with their properties in vitro, whereas their in vivo behavior still remains poorly studied. However, an enormous potential of these highly biocompatible carriers for in vivo applications is undoubted. This last issue is addressed in depth in the Conclusion and Outlook sections of the review.

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Section: A B Cmentioning

confidence: 99%

Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Biny,

Gerasimovich,

Karaulov

et al. 2024

Preprint

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show abstract

“…Porous calcium carbonates and phosphates have demonstrated their potential as effective drug carriers due to their biocompatibility and biodegradability [238][239][240]. Miyamaru et al designed and synthesized peptide lipids with specific sequences, which were then incorporated into vesicles and mineralized to create CaCO 3 -coated vesicles [241].…”

Section: Drug Delivery Applicationmentioning

confidence: 99%

Biomineral-Based Composite Materials in Regenerative Medicine

Kim,

Ki,

Han

et al. 2024

IJMS

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Regenerative medicine aims to address substantial defects by amplifying the body’s natural regenerative abilities and preserving the health of tissues and organs. To achieve these goals, materials that can provide the spatial and biological support for cell proliferation and differentiation, as well as the micro-environment essential for the intended tissue, are needed. Scaffolds such as polymers and metallic materials provide three-dimensional structures for cells to attach to and grow in defects. These materials have limitations in terms of mechanical properties or biocompatibility. In contrast, biominerals are formed by living organisms through biomineralization, which also includes minerals created by replicating this process. Incorporating biominerals into conventional materials allows for enhanced strength, durability, and biocompatibility. Specifically, biominerals can improve the bond between the implant and tissue by mimicking the micro-environment. This enhances cell differentiation and tissue regeneration. Furthermore, biomineral composites have wound healing and antimicrobial properties, which can aid in wound repair. Additionally, biominerals can be engineered as drug carriers, which can efficiently deliver drugs to their intended targets, minimizing side effects and increasing therapeutic efficacy. This article examines the role of biominerals and their composite materials in regenerative medicine applications and discusses their properties, synthesis methods, and potential uses.

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“…The loading capacity of these systems depends on several factors, such as the porosity and specific surface area of the CaCO 3 particles and the chemical properties of the drug. Studies have shown significant effectiveness of low-molecular-weight drug encapsulation [30] and their controlled release from CaCO 3 cores [31], sometimes with a reduced cytotoxicity [32]. The efficiency of encapsulation and stability of encapsulated molecules have been also demonstrated for proteins [33] and nucleic acids [34].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Calcium Carbonate-Based Microparticles as a Versatile Tool for Targeted Drug Delivery and Cancer Treatment

Biny,

Gerasimovich,

Karaulov

et al. 2024

Pharmaceutics

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Nano- and microparticles are increasingly widely used in biomedical research and applications, particularly as specific labels and targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it has some disadvantages limiting its potential, such as the proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being an easily available, cost-effective, and biocompatible material with high porosity and surface reactivity, which makes it an attractive choice for targeted drug delivery. CaCO3 particles are used in this field in the form of either bare CaCO3 microbeads or core/shell microparticles representing polymer-coated CaCO3 cores. In addition, they serve as removable templates for obtaining hollow polymer microcapsules. Each of these types of particles has its specific advantages in terms of biomedical applications. CaCO3 microbeads are primarily used due to their capacity for carrying pharmaceutics, whereas core/shell systems ensure better protection of the drug-loaded core from the environment. Hollow polymer capsules are particularly attractive because they can encapsulate large amounts of pharmaceutical agents and can be so designed as to release their contents in the target site in response to specific stimuli. This review focuses first on the chemistry of the CaCO3 cores, core/shell microbeads, and polymer microcapsules. Then, systems using these structures for the delivery of therapeutic agents, including drugs, proteins, and DNA, are outlined. The results of the systematic analysis of available data are presented. They show that the encapsulation of various therapeutic agents in CaCO3-based microbeads or polymer microcapsules is a promising technique of drug delivery, especially in cancer therapy, enhancing drug bioavailability and specific targeting of cancer cells while reducing side effects. To date, research in CaCO3-based microparticles and polymer microcapsules assembled on CaCO3 templates has mainly dealt with their properties in vitro, whereas their in vivo behavior still remains poorly studied. However, the enormous potential of these highly biocompatible carriers for in vivo applications is undoubted. This last issue is addressed in depth in the Conclusions and Outlook sections of the review.

show abstract

Application of Calcium Carbonate as a Controlled Release Carrier for Therapeutic Drugs

Cited by 5 publications

References 33 publications

Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Biomineral-Based Composite Materials in Regenerative Medicine

Functionalized Calcium Carbonate-Based Microparticles as a Versatile Tool for Targeted Drug Delivery and Cancer Treatment

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