Application of capillary electrophoresis-electrospray ionisation mass spectrometry to arsenic speciation

Schramel, O.; Michalke, Bernhard; Kettrup, A.

doi:10.1039/a900494g

Cited by 35 publications

(35 citation statements)

References 20 publications

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“…[61,62]. Several parameters, including type, pH buffer, and ionic strength of the buffer, applied voltage, temperature of the capillary, and dimensions of the capillary, need to be considered to optimize the separation process [63]. As(III), As(V), DMA, MMA(V), AsB, and AsC were separated by using capillary zone electrophoresis (CZE) coupled with ICP-MS detection.…”

Section: Capillary Electrophoresismentioning

confidence: 99%

Application of Organometallic Speciation in Clinical Studies

Yuan

Sun

et al. 2012

Analytical Techniques for Clinical Chemistry

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Section: Capillary Electrophoresismentioning

confidence: 99%

Application of Organometallic Speciation in Clinical Studies

Yuan

Sun

et al. 2012

Analytical Techniques for Clinical Chemistry

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“…In the CE-ESI-MS system, where for geometrical reasons a long (100 cm) capillary has to be used, the application of additional pressure has shortened analysis time dramatically [58]. A system with 30 mM ammonium acetate/acetic acid buffer of pH 6 as leading electrolyte and 25% acetic acid as terminating electrolyte was used.…”

Section: Arsenicmentioning

confidence: 99%

Speciation of oxidation states of elements by capillary electrophoresis

Trojanowicz¹,

Poboży

2003

J of Separation Science

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Speciation of oxidation states of elements by capillary electrophoresisProgress made in the last five years in the application of capillary electrophoresis methods to chemical speciation of elements is reported on the basis of over 100 literature references. The main trends observed include development of new on-and offcapillary derivatization methods, application of new detection methods, and especially coupling of CE separation systems to powerful atomic spectroscopy and mass spectrometry instruments with various ionization techniques, providing either a sensitive element-specific detection method or a third dimension for high performance separation. Besides numerous CZE and MEKC capillary electrophoresis methods only very few examples of CE speciation with capillary electrochromatography can be found. Concerning the chemical forms of elements determined, the new procedures developed are mostly focused on redox speciation of various oxidation states of elements, metal-bound high molecular compounds, and organometallic species.

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“…25 Schramel et al employed a more elaborate separation protocol that was based on sample stacking. 23 In addition, they investigated the effect of pressure-driven separation approaches (high and low pressure) on migration times, peak symmetry, resolution and detection limits. However, pressure was not applied until 10 min after injection.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19][20][21][22][23][24][25][26] However, the number of studies dealing with the analysis of AsB and AsC by CE hyphenated to MS detection is very limited. [23][24][25][26] One of the main issues of CE-ESI-MS measurements is the generally long migration times since the setup generally requires the use of long capillaries (up to 100 cm or longer), especially when working with commercial instruments. Typical total separation times for AsB and AsC range between 16 min 23 and 20 min.…”

Section: Introductionmentioning

confidence: 99%

“…The main advantages include its low buffer consumption, high resolution power and low sample requirement. CE has been successfully employed for arsenic speciation analysis [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] with its focus on elemental speciation analysis and the determination of inorganic species and the methylated arsenic acids (e.g., DMA, monomethylarsonic acid). AsB, AsC and phenylarsenic species (e.g., roxarsone) were frequently included in those studies.…”

Section: Introductionmentioning

confidence: 99%

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Fast separations by capillary electrophoresis hyphenated to electrospray ionization time-of-flight mass spectrometry as a tool for arsenic speciation analysis

Niegel

Pfeiffer

Grundmann

et al. 2012

Analyst

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Fast capillary electrophoresis (CE) hyphenated to time-of-flight mass spectrometry (TOF-MS) of four organoarsenic species (glycerol oxoarsenosugar, sulfate oxoarsenosugar, arsenobetaine, arsenocholine) are presented using short length CE capillaries under high electric field strengths of up to 1.3 kV cm À1 with small inner diameter (ID). The separation of arsenosugars by CE is demonstrated for the first time. An aqueous formic acid solution was employed as the background electrolyte (BGE) for the separation. Various acid concentrations were evaluated for their influence on migration times, separation efficiency as well as with regard to controlling the charge of the arsenic species. A 0.1 M formic acid/ammonium formate buffer (pH 2.8) proved to be suitable for the separation of the four species. A non-aqueous BGE was tested as an alternative buffer system for fast speciation analysis. Separation of arsenobetaine and arsenocholine could even be achieved within 10 s by pressure-assisted CE. Application of the optimized method for the analysis of extracts of a seagrass and a Wakame algae sample as well as the brown algae homogenate reference material IAEA-140/TM revealed a clear signal for the glycerol arsenosugar.

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Application of capillary electrophoresis-electrospray ionisation mass spectrometry to arsenic speciation

Cited by 35 publications

References 20 publications

Application of Organometallic Speciation in Clinical Studies

Application of Organometallic Speciation in Clinical Studies

Speciation of oxidation states of elements by capillary electrophoresis

Fast separations by capillary electrophoresis hyphenated to electrospray ionization time-of-flight mass spectrometry as a tool for arsenic speciation analysis

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