2020
DOI: 10.1002/elps.202000154
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Application of capillary electrophoresis technique for the enantioseparation of bioactive ferrocene‐based compounds versus DFT calculated data

Abstract: Herein, a series of bioactive ferrocene‐modified N‐heterocycles with alkyl linkers was prepared in good to quantitative yields starting from easy accessible ferrocene alcohols and heterocycles under acidic or neutral (for imidazole) conditions in racemic forms. The analytical resolution of a number of bioactive racemic ferrocene azoles 1–6 (where azole = imidazole, pyrazole, and benzotriazole derivatives) into enantiomers was first carried out by CE using sulfobuthylether‐β‐CD (captisol) as a chiral selector. … Show more

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Cited by 5 publications
(7 citation statements)
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“…The method enabled direct determination of the enantiomers of tetrahydropalmatine and canadine in the complex samples of Corydalis Rhizoma with low LOD of 0.017 μg g –1 and good recovery of 89.1%–110.0% . Sulfated-β-CD (S-β-CD) and sulfobuthylether-β-CD sodium (SBE-β-CD) were used in chiral CE separation of racemic bioactive ferrocene-modified azoles and chiral fluoroquinolones, respectively. , Ionic liquid modified SBE-β-CD was also prepared to give a superior CE enantio-separation for racemic drugs to original SBE-β-CD . Sulfated-γ-CD (HS-γ-CD) was employed as CE chiral selector to investigate the enantioselective biodegradation of citalopram and verapamil .…”
Section: Capillary Electrophoresismentioning
confidence: 99%
“…The method enabled direct determination of the enantiomers of tetrahydropalmatine and canadine in the complex samples of Corydalis Rhizoma with low LOD of 0.017 μg g –1 and good recovery of 89.1%–110.0% . Sulfated-β-CD (S-β-CD) and sulfobuthylether-β-CD sodium (SBE-β-CD) were used in chiral CE separation of racemic bioactive ferrocene-modified azoles and chiral fluoroquinolones, respectively. , Ionic liquid modified SBE-β-CD was also prepared to give a superior CE enantio-separation for racemic drugs to original SBE-β-CD . Sulfated-γ-CD (HS-γ-CD) was employed as CE chiral selector to investigate the enantioselective biodegradation of citalopram and verapamil .…”
Section: Capillary Electrophoresismentioning
confidence: 99%
“…Despite this, these metallocenes were not comprehensively explored in enantioseparation science, and very few systematic analytical and mechanistic studies about the function of the (η 5 -C 5 H 5 )Fe(η 5 -C 5 H 5 ) core in chromatographic and electromigration processes were reported so far. Coherently to this statement, only two recent studies about the enantioseparation of chiral ferrocenes by CE are available in the literature [16,51], even if in the past CE had found application in the analytical separation of mixtures of ferrocene derivatives [52,53].…”
Section: Enantioseparation Of Chiral Ferrocenes (2020s)mentioning
confidence: 99%
“…Later, other CD-based CSPs were used for the enantioseparation of ferrocenes featured by central chirality exclusively [51,[173][174][175]. Recently, sulfobutylether-β-CD was used as a chiral selector for the CE enantioseparation of chiral ferrocenes exclusively containing a chiral centre, as a chiral element [176].…”
Section: Enantioseparation Of Planar Chiral Ferrocenesmentioning
confidence: 99%