Application of capillary electrophoresis to the simultaneous screening and quantitation of benzodiazepines

Tomita, Masafumi; Okuyama, Toshiko

doi:10.1016/0378-4347(95)00512-9

Cited by 49 publications

(21 citation statements)

References 31 publications

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“…A multiplexed capillary with UV detection is quite suitable for high-throughput analysis in pharmaceutical studies. Amphetamines [155], benzodiazepines [156], bufotenine, psilocybin and related indole alkaloids [157], clenbuterol (chiral analysis with added CDs) [158], cocaine [159], codeine pharmaceuticals [160], g-hydroxybutyrate [161], prion protein [162], and serum procainamide [163] are a few examples of the important drugs which have been detected by CE. Pharmacokinetic studies require sensitive and quantitative analyses that can be used in systems-based representations of medical systems, as can be seen in the review published by Lin et al [164].…”

Section: Ce In Pharmaceuticsmentioning

confidence: 99%

Capillary electrophoresis at the omics level: Towards systems biology

et al. 2006

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Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high-throughput, sensitive, precise, and accurate analytical instrumentation and technological innovation. Separation sciences play an important role in revealing biological processes at various omic levels. From the perspective of systems biology, CE is a strong candidate for high-throughput, sensitive data generation which is capable of tackling the challenges in acquiring qualitative and quantitative knowledge through a system-level study. This review focuses on the applicability of CE to systems-based analytical data at the genomic, transcriptomic, proteomic, and metabolomic levels.

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Section: Ce In Pharmaceuticsmentioning

confidence: 99%

Capillary electrophoresis at the omics level: Towards systems biology

et al. 2006

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“…Jinno et al [105] described an MEKC method for benzodiazepines in urine; the detection was accomplished spectrophotometrically for a concentration of about 1 ppm. Similarly other papers report the determination of benzodiazepine levels in serum by MEKC [106][107][108]. All the described methods are briefly schematized in Table 8.…”

Section: Benzodiazepinesmentioning

confidence: 99%

Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography

Pucci

Raggi

2005

Electrophoresis

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An overview of the electrokinetic chromatographic methods for the analysis of antiepileptic drug levels in biological samples is presented. In particular, micellar electrokinetic capillary chromatography is a very suitable method for the determination of these drugs, because it allows a rapid, selective, and accurate analysis. In addition to the electrokinetic chromatographic studies on the determination of antiepileptic drugs, some information regarding sample pretreatment will also be reported: this is a critical step when the analysis of biological fluids is concerned. The electrokinetic chromatographic methods for the determination of recent antiepileptic drugs (e.g., lamotrigine, levetiracetam) and classical anticonvulsants (e.g., carbamazepine, phenytoin, ethosuximide, valproic acid) will be discussed in depth, and their pharmacological profiles will be briefly described as well.

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“…Les coefficients de variation de la répétabilité et de la reproductibilité peuvent varier respectivement de 2 à 8 % et 3 à 12 % (18,44,65,67). Les nombreux facteurs pouvant influencer ces valeurs ont été étudiés par Watzig (71) : stabilité de la température pendant l'injection influençant la viscosité du solvant d'injection, electrolyse du tampon de migration avec acidification à l'anode à l'origine de modifications de t M , meilleure reproductibilité des résultats obtenus en injection hydrodynamique, importance du pouvoir tampon des phases de migration.…”

Section: -Traitement Des Données Et Validation Des Résultatsunclassified