Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C<sup>4</sup>D): An update

Elbashir, Abdalla A.; Schmitz, Oliver J.; Aboul‐Enein, Hassan Y.

doi:10.1002/bmc.3945

Cited by 21 publications

(9 citation statements)

References 80 publications

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“…In addition, advances in electrochemical detectors, such as CE-contactless coupled detection (CE-CCD) and CE-capacitively coupled contactless conductivity detection (CE-C 4 D), offered very sensitive methods [22,23]. Furthermore, the development of miniaturized CE systems (microchip-CE devices) allowed the monitoring of food analytes with rapidity and sensitivity, and their use was particularly important in the detection of frauds or contaminations [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Colombo

Papetti

2019

Molecules

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In the last years, the European Commission has adopted restrictive directives on food quality and safety in order to protect animal and human health. Veterinary drugs represent an important risk and the need to have sensitive and fast analytical techniques to detect and quantify them has become mandatory. Over the years, the availability of different modes, interfaces, and formats has improved the versatility, sensitivity, and speed of capillary electrophoresis (CE) techniques. Thus, CE represents a powerful tool for the analysis of a large variety of food matrices and food-related molecules with important applications in food quality and safety. This review focuses the attention of CE applications over the last decade on the detection of different classes of drugs (used as additives in animal food or present as contaminants in food products) with a potential risk for animal and human health. In addition, considering that the different sample preparation procedures have strongly contributed to CE sensitivity and versatility, the most advanced sample pre-concentration techniques are discussed here.

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Section: Introductionmentioning

confidence: 99%

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Colombo

Papetti

2019

Molecules

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“…To demonstrate the applicability of the proposed approach, plasma samples from patients under treatment with TPM were analyzed according to the procedure described. It is important to mention that while the combination of CE‐C 4 D has been previously used for the analysis of small molecules including pharmaceutical compounds such as sildenafil/vardenafil , caffeine/paracetamol/ibuprofen , or antibiotics the application to serum samples is rarely reported. Figure shows the results obtained from 10 patients under treatment with TPM.…”

Section: Resultsmentioning

confidence: 99%

Determination of topiramate by capillary electrophoresis with capacitively‐coupled contactless conductivity detection: A powerful tool for therapeutic monitoring in epileptic patients

et al. 2018

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Topiramate (TPM) is the main antiepileptic drug used for the control of partial and generalized seizures in both adults and children. In association with clinical observations, the analysis of plasmatic concentration of TPM is of utmost importance for the individual adjustment of the administered dose to the patient. In the present work, a bioanalytical method was developed and validated for TPM analysis in plasma samples by capillary electrophoresis with capacitively-coupled contactless conductivity detection (CE-C D). A simple background electrolyte composed of 15 mmol/L triethylamine, hydrodynamic injections (0.8 psi for 5 s) and a moderate separation voltage (20 kV) were used, rendering relatively short analysis times (<3 min). The sample pre-treatment was carried out by liquid-liquid extraction using methyl terc-butyl ether as solvent and 200 μL of plasma. The method was validated according to the official guidelines from the European Medicine Agency and showed linearity in plasmatic concentration range from 1 to 30 μg/mL, which covers the clinically-relevant interval. The lower limit of quantification of 1 μg/mL obtained also allows following patients with low dosage of the drug. The method was successfully applied to analysis of plasma samples and allowed the identification of 80% under-medicated patients in the analyzed patient pool.

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“…Elbashir et al. reviewed the applications of CE‐axial C 4 D to analyses in the pharmaceutical and biological fields and concluded that this approach was showing great promise. Wang et al.…”

Section: Applications In Different Clinical Fieldsmentioning

confidence: 99%

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Phillips

2017

Electrophoresis

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Recent advances in CE and microchip-CE in clinical applications: 2014 to mid-2017CE and microchip CE (ME) are powerful tools for the analysis of a number of different analytes and have been applied to a variety of clinical fields and human samples. This review will present an overview of the most recent applications of these techniques to different areas of clinical medicine during the period of 2014 to mid-2017. CE and ME have been applied to clinical chemistry, drug detection and monitoring, hematology, infectious diseases, oncology, endocrinology, neonatology, nephrology, and genetic screening. Samples examined range from serum, plasma, and urine to lest utilized materials such as tears, cerebral spinal fluid, sweat, saliva, condensed breath, single cells, and biopsy tissue. Examples of clinical applications will be given along with the various detection systems employed.

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Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Cited by 21 publications

References 80 publications

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Determination of topiramate by capillary electrophoresis with capacitively‐coupled contactless conductivity detection: A powerful tool for therapeutic monitoring in epileptic patients

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

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Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D): An update

Cited by 21 publications

References 80 publications

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Advances in the Analysis of Veterinary Drug Residues in Food Matrices by Capillary Electrophoresis Techniques

Determination of topiramate by capillary electrophoresis with capacitively‐coupled contactless conductivity detection: A powerful tool for therapeutic monitoring in epileptic patients

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

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Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update