Application of capillary supercritical fluid chromatography–double focusing mass spectrometry under negative ion chemical ionization conditions

Huang, Eric C.; Jackson, Bruce J.; Markides, Karin E.; Lee, Milton L.

doi:10.1002/mcs.1220020209

Cited by 10 publications

(2 citation statements)

References 29 publications

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“…Interesting though is the isolated appearance of O − in the ion source, when under the same conditions amphetamine isomers have shown the repeated emergence of carbon dioxide adduct ions. The presence of CO − 2 has been reported in other systems [18], however, its apparent absence from our reagent gas studies would tend to suggest that neutral CO 2 adds to the amine anion.…”

Section: Negative Ion Chemistry Of the Carbon Dioxide Plasmamentioning

confidence: 41%

“…Negative ion chemical ionization (NICI) has been used in mass spectrometry for many years as a means of obtaining more structural information about compounds through specific ion molecule reactions with a variety of reagent gases [13][14][15][16]. The use of carbon dioxide in NICI was not very common until the coupling of supercritical fluid chromatography (SFC) with MS inevitably began demonstrating some of its analytical utility [17,18]. Since then carbon dioxide NICI has provided assistance in several demanding applications such as isomer discrimination among nitroso compounds [19] and polycyclic aromatic hydrocarbons [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Discrimination of structural isomers of amphetamine using carbon dioxide negative‐ion chemical ionization mass spectrometry

Thurbide

Elson

Sim

1996

Journal of Spectroscopy

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The negative‒ion chemical ionization mass spectra of a group of structural isomers of amphetamine have been studied using carbon dioxide as the reagent gas. Characteristic and reproducible differences are observed for each member of the set implying that this technique offers a means of distinguishing among groups of amphetamine isomers. Characteristic adducts to the molecular ion are observed in the form (M–[H]+[O]) and (M–[H]+[CO2]). Descriptions of some fragments are given based on the mass spectral behaviour of a set of analogue compounds and the results of oxygen-18 labelled carbon dioxide reagent gas experiments. Contents of the carbon dioxide plasma and their impact on various analytes is also discussed.

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Section: Negative Ion Chemistry Of the Carbon Dioxide Plasmamentioning

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Discrimination of structural isomers of amphetamine using carbon dioxide negative‐ion chemical ionization mass spectrometry

Thurbide

Elson

Sim

1996

Journal of Spectroscopy

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Explosives Analysis in the Environment

Tomkins

2000

Encyclopedia of Analytical Chemistry

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The interest in analytical procedures for explosives residues in environmental media steadily increases as more and more formerly utilized military sites are certified and converted to full‐ or part‐time civilian use. Careful statistical studies have clearly demonstrated that analyses based on randomly collected “grab” samples of soils frequently produce a false picture of the extent of explosives contamination. Well‐designed sampling plans, which employ multiple samples taken from small areas and which consider the distribution of the soil particles, are mandatory for understanding the true extent of contamination. Because site remediation is such a costly venture, there is a strong need for analytical procedures which are capable of quantitating explosives in soil and groundwater samples quickly and accurately, using equipment and methods which may be operated reliably by nontechnical personnel. For that reason, scientific interest is gradually moving away from the completely laboratory‐based, statistically validated, and highly technical standardized methods, such as high‐pressure liquid chromatography (HPLC) and gas chromatography (GC) and their mass spectroscopic analogs, towards the many fieldable analytical techniques. Some of these, such as ion mobility spectrometry and the various magnetic resonance techniques, are still in their infancy; their potential and utility are still to be fully developed. Others, such as the colorimetric and enzyme‐based field test kits, have been fully tested and, in some cases, have been adopted as standard methods themselves. Still others, such as the various mass spectrometric methods, involve highly technical equipment which must be simplified before it can be used routinely in the field. However, the extreme sensitivities characteristic of these state‐of‐the‐art instruments partially offset the need for extensive operator training. A variety of mass spectrometric techniques may yet be used routinely for explosives residue analysis in the field. Some of these new methods may be used in, or even be derived from, forensic applications.

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The application of capillary SFC, packed column SFC, and capillary SFC‐MS in the analysis of controlled drugs

Mackay¹,

Reed²

1991

J. High Resol. Chromatogr.

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Multi-component mixtures of controlled drugs, drug impurities, and adulterants have been analyzed by capillary SFC-FID, capillary column SFC-MS [7] and Olesik [8] has surveyed recent advances in SFC-MS. packed column SFC-UV, and capillary SFC-MS. lsocratic packed column SFC has been performed with binary and ternary mobile phases using a single syringe pump.The combination of capillary SFC and double focusing MS is described with reference to MS source pressures and the spectra obtained.The use of negative temperature programming in SFC is described. ~ 0 British Crown Copyright

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Application of capillary supercritical fluid chromatography–double focusing mass spectrometry under negative ion chemical ionization conditions

Cited by 10 publications

References 29 publications

Discrimination of structural isomers of amphetamine using carbon dioxide negative‐ion chemical ionization mass spectrometry

Discrimination of structural isomers of amphetamine using carbon dioxide negative‐ion chemical ionization mass spectrometry

Explosives Analysis in the Environment

The application of capillary SFC, packed column SFC, and capillary SFC‐MS in the analysis of controlled drugs

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