Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate

Seo, Jeong-Woo; Jo, Sung-Han; Kim, Seon-Hwa; Choi, Byeong-Hoon; Cho, Hongsik; Yoo, James J.; Park, Sang-Hyug

doi:10.1007/s13770-023-00587-0

Tissue Eng Regen Med

2023

DOI: 10.1007/s13770-023-00587-0

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Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate

Jeong-Woo Seo,

Sung-Han Jo,

Seon-Hwa Kim

et al.

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2024

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Cited by 2 publications

References 56 publications

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Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs

Chen,

Fan,

et al. 2024

Advanced Science

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Accurate affinity assessments play an important role in drug discovery, screening, and efficacy evaluation. Label‐free affinity biosensors are recognized as a dependable and standard technology for addressing this challenge. This study constructs a free electron density gradient‐enhanced meta‐surface plasmon resonance (FED‐MSPR) biosensor through a finite‐difference time‐domain simulation model, the biosensor demonstrates superior detection performance in accurately determining affinity and kinetic rate constants. By controlling the dielectric properties of the metal on the surface of the nanocup arrays, the plasmon resonance effects are easily tuned without changing the nanostructure design. Compared with the single‐layer gold chip, the triple‐layer FED‐MSPR chip demonstrated a four‐fold improvement in resolution at the optimal resonance peak. Additionally, the sensitivity and figure of merit (FOM) of the multi‐layer chip increased by 3.5 and 7.99 times, respectively. Following modification with high‐ and low‐staggered carboxylation, the noise‐signal ratio and baseline stability of the real‐time kinetic curves based on these chips are significantly enhanced. The developed carboxylation FED‐MSPR platform is successfully used to perform affinity assays for Adalimumab and TNF‐α protein, resulting in favorable dynamic curves. These findings validate the proposed FED‐MSPR biosensor platform as cost‐effective, rapid, sensitive, and label‐free, facilitating real‐time quality control in drug development.

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Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs

Chen,

Fan,

et al. 2024

Advanced Science

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Decellularized extracellular matrix-based hydrogels for cartilage repair and regeneration

Xu,

Jiang,

Zhu

et al. 2024

Advanced Orthopaedics

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Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate

Cited by 2 publications

References 56 publications

Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs

Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs

Decellularized extracellular matrix-based hydrogels for cartilage repair and regeneration

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