Application of chitosan-based nanoparticles in skin wound healing

Loo, Hooi Leong; Goh, Bey Hing; Lee, Learn‐Han; Chuah, Lay Hong

doi:10.1016/j.ajps.2022.04.001

Cited by 90 publications

(28 citation statements)

References 187 publications

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“…Further research, particularly in vivo studies, will still be necessary to thoroughly evaluate the potential toxicity and effects of CS‐NPs on human cells in a surgical context. However, based on the current body of evidence in wound healing, it is reasonable to suggest that CS‐NPs could be used safely as an antimicrobial component in surgical irrigation fluids 22 …”

Section: Discussionmentioning

confidence: 99%

The potential of suspended chitosan nanoparticles as a surgical irrigation fluid

Holmes

Narro

Jones

et al. 2023

Journal Orthopaedic Research

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In this study, we sought to synthesize chitosan nanoparticles (CS‐NPs) and characterize their morphology, efficacy in inhibiting bacterial attachment, and efficacy in eradicating bacteria established on implantable hardware. CS‐NPs possess desirable properties, including antibacterial properties in biofilm‐mediated infections. CS‐NPs were produced using ionic gelation and characterized via scanning electron microscope imaging. Staphylococcus aureus was incubated with CS‐NPs at various concentrations and compared to a 1% povidone‐iodine with 1% H2O2 control in 24‐well plates. Stainless steel bone screws were placed in six‐well plates and inoculated with S. aureus. After 24 h, the screws were transferred to one of three solutions (saline, 40 mg/mL CS‐NP, or 1% povidone‐iodine with 1% H2O2). Four screws from each group were vortexed in saline and plated. The remaining screw from each group was prepped and imaged to map the location of persistent bacteria. Synthesized CS‐NPs had a mean diameter of 0.39 ± 0.13 μm and circularity of 0.87 ± 0.05. The percent inhibition of bacterial attachment was 73% at 20 mg/mL, 73% at 30 mg/mL, 75% at 40 mg/mL, 79% at 50 mg/mL, and 78% at 60 mg/mL. When compared to saline, the 40 mg/mL CS‐NP solution reduced bacteria on the screws by 76%. No bacteria were retrieved from the 1% povidone‐iodine with 1% H2O2 group. This study demonstrated that CS‐NP solution effectively inhibited S. aureus bacterial attachment and was more effective than saline in eradicating bacteria from orthopedic hardware, suggesting that CS‐NPs have the potential for prevention and treatment of musculoskeletal infections as a component of an intraoperative surgical irrigation solution.

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Section: Discussionmentioning

confidence: 99%

The potential of suspended chitosan nanoparticles as a surgical irrigation fluid

Holmes

Narro

Jones

et al. 2023

Journal Orthopaedic Research

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“…On one hand, activation of angiogenesis during wound healing improves tissue trophism, decreases the level of hypoxia and the migration/proliferation of cells 28 , 29 . On the other hand, inadequate activation of neoangiogenesis leads to hypertrophic scar formation 30 . ES protein, secreted granulin-like growth factor termed Ov-GRN-1 O. viverrini , have previously been shown to accelerate angiogenesis and wound healing in mice in vitro 31 .…”

Section: Discussionmentioning

confidence: 99%

Wound healing approach based on excretory-secretory product and lysate of liver flukes

Ковнер

Tarasenko

Zaparina

et al. 2022

Sci Rep

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Exogenous bioactive peptides are considered promising for the wound healing therapy in humans. In this regard, parasitic trematodes proteins may potentially become a new perspective agents. Foodborne trematode Opisthorchis felineus is widespread in Europe and has the ability to stimulate proliferation of bile duct epithelium. In this study, we investigated skin wound healing potential of O. felineus proteins in mouse model. C57Bl/6 mice were inflicted with superficial wounds with 8 mm diameter. Experimental groups included several non-specific controls and specific treatment groups (excretory-secretory product and lysate). After 10 days of the experiment, the percentage of wound healing in the specific treatment groups significantly exceeded the control values. We also found that wound treatment with excretory-secretory product and worm lysate resulted in: (i) inflammation reducing, (ii) vascular response modulating, (iii) type 1 collagen deposition promoting dermal ECM remodeling. An additional proteomic analysis of excretory-secretory product and worm lysate samples was revealed 111 common proteins. The obtained data indicate a high wound-healing potential of liver fluke proteins and open prospects for further research as new therapeutic approaches.

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“…Furthermore, the potential ability of nanosystems to penetrate the barrier function of the skin have been investigated and illustrated [ 175 , 176 ]. However, there is controversy regarding the characteristics of nanosystems that affect their skin penetration.…”

Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

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Application of chitosan-based nanoparticles in skin wound healing

Cited by 90 publications

References 187 publications

The potential of suspended chitosan nanoparticles as a surgical irrigation fluid

The potential of suspended chitosan nanoparticles as a surgical irrigation fluid

Wound healing approach based on excretory-secretory product and lysate of liver flukes

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

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