Application of citrate-stabilized gold-coated ferric oxide composite nanoparticles for biological separations

Pham, Thao T. H.; Cao, Cuong; Sim, Sang Jun

doi:10.1016/j.jmmm.2008.03.015

Cited by 121 publications

(28 citation statements)

References 20 publications

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“…In most cases, hydroxylamine, citrate, and borohydride have been used as reducing agents in combination with the reverse micelle technique for reducing gold salt nanoparticles [13,18,20,21]. Tamer et al [19] reported a two-step synthetic method in which the magnetite nanoparticles were coated with gold using the borohydride reduction of HAuCl 4 under sonication in order to achieve a better monodispersity and prevent aggregation problems.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure

et al. 2012

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BackgroundFe3O4-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.ResultsMagnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe3O4 monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au3+ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution.ConclusionsA rapid, mild method for synthesizing Fe3O4-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized.

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Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure

et al. 2012

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“…The synthesis and properties of metallic nanoparticles (NPs) has been extensively studied over decades, not only because of their unique properties, but also because of their potential applications in catalysis, electronics, optoelectronics, information storage, biosensors, and surface-enhanced Raman spectroscopy (SERS) [1][2][3][4][5][6][7][8][9][10]. Nanoparticles can exist as common structural elements or composites, and they have a wide functional diversity compared to bulk materials.…”

Section: Introductionmentioning

confidence: 99%

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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Metal nanoparticles are extensively studied due to their unique chemical and physical properties, which differ from the properties of their respective bulk materials. Likewise, the properties of heterogeneous bimetallic structures are far more attractive than those of single-component nanoparticles. For example, the incorporation of a second metal into a nanoparticle structure influences and can potentially enhance the optical/plasmonic and magnetic properties of the material. This review focuses on the enhanced optical/plasmonic and magnetic properties offered by bimetallic nanoparticles and their corresponding impact on biological applications. In this review, we summarize the predominant structures of bimetallic nanoparticles, outline their synthesis methods, and highlight their use in biological applications, both diagnostic and therapeutic, which are dictated by their various optical/plasmonic and magnetic properties.

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“…The greater the degree of substitution, the smaller the NP [21]. NP size is related to targeting and cell uptake efficiency [22,23]. The surface of polymer hydrophilic groups modifying amino derivatives or carboxylic acid derivatives, and hydrophobic groups participate in the NP self-assembly process [24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Cholesterol-Modified Amino-Pullulan Nanoparticles as a Drug Carrier: Comparative Study of Cholesterol-Modified Carboxyethyl Pullulan and Pullulan Nanoparticles

et al. 2016

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To search for nano-drug preparations with high efficiency in tumor treatment, we evaluated the drug-loading capacity and cell-uptake toxicity of three kinds of nanoparticles (NPs). Pullulan was grafted with ethylenediamine and hydrophobic groups to form hydrophobic cholesterol-modified amino-pullulan (CHAP) conjugates. Fourier transform infrared spectroscopy and nuclear magnetic resonance were used to identify the CHAP structure and calculate the degree of substitution of the cholesterol group. We compared three types of NPs with close cholesterol hydrophobic properties: CHAP, cholesterol-modified pullulan (CHP), and cholesterol-modified carboxylethylpullulan (CHCP), with the degree of substitution of cholesterol of 2.92%, 3.11%, and 3.46%, respectively. As compared with the two other NPs, CHAP NPs were larger, 263.9 nm, and had a positive surface charge of 7.22 mV by dynamic light-scattering measurement. CHAP NPs showed low drug-loading capacity, 12.3%, and encapsulation efficiency of 70.8%, which depended on NP hydrophobicity and was affected by surface charge. The drug release amounts of all NPs increased in the acid media, with CHAP NPs showing drug-release sensitivity with acid change. Cytotoxicity of HeLa cells was highest with mitoxantrone-loaded CHAP NPs on MTT assay. CHAP NPs may have potential as a high-efficiency drug carrier for tumor treatment.

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Application of citrate-stabilized gold-coated ferric oxide composite nanoparticles for biological separations

Cited by 121 publications

References 20 publications

Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure

Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Cholesterol-Modified Amino-Pullulan Nanoparticles as a Drug Carrier: Comparative Study of Cholesterol-Modified Carboxyethyl Pullulan and Pullulan Nanoparticles

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