Given the current climate emergency and the ambitious targets of carbon emissions reduction, retrofitting strategies on existing buildings typically include reducing energy demand, decarbonising the power supply, and addressing embodied carbon stored in materials. This latter point redefines the role of engineers in the transitions towards a sustainable construction sector, being they responsible for designing low impact, sustainable and carbon neutral solutions. A Life Cycle Structural Engineering (LCSE) approach, inspired by the principles of Life Cycle Thinking (LCT), should thus be adopted for the sustainable renovation of existing buildings. Only recently have pioneering approaches been proposed, tackling multifaceted buildings’ needs, such as those related to energy consumption as well as seismic safety, but often disregarding LCT principles. This study presents a redefinition of the concept of LCSE for sustainable construction and a comprehensive review of available methods and tools to operationalise the LCSE approach in practice, focusing on the consideration of LCT principles in the retrofitting design process, integration of seismic loss estimation and environmental impact assessment, and implementation of integrated retrofitting strategies. The greatest ambition of this work is thus to boost a paradigm shift for building engineers towards an interdisciplinary perspective in building assessment and retrofitting.