Application of coated green source carbon dots with silica molecularly imprinted polymers as a fluorescence probe for selective and sensitive determination of phenobarbital
“…In other words, if the fluorescence spectra of MIP overlaps with the UV-Vis spectra of the target molecule, the target molecule acts as a fluorescence absorber for MIP-CDs, which leads to energy transfer. 18,33,36 In this study, according to Fig. 4, since there is no overlap between the MIP-CDs fluorescence spectra and the UV-Vis spectra of the target molecule (propranolol), the energy transfer mechanism is not possible.…”
In this article, a new optical sensor was developed using a molecularly imprinted polymers layer coated with new green carbon dots (CDs) for the determination of propranolol. First, the CDs were synthesized for the first time from Cedrus plant through the hydrothermal method. Then, a nanolayer molecularly imprinted polymer (MIP) was applied on the CDs (MIP-CDs) in the presence of propranolol as a template using a reverse microemulsion technique. Afterward, propranolol was removed from MIP-CDs nanocomposites using a mixture of ethanol and acetonitrile, and the obtained nanocomposite was used as a fluorescence sensor for propranolol determination. Under the optimal conditions, the sensor response was linear in the range of 0.8 -65.0 nmol L -1 with a detection limit of 0.2 nmol L -1 . The results confirmed that the sensor has some advantages such as cost-effectiveness, rapid response, high sensitivity and selectivity for propranolol determination.
“…In other words, if the fluorescence spectra of MIP overlaps with the UV-Vis spectra of the target molecule, the target molecule acts as a fluorescence absorber for MIP-CDs, which leads to energy transfer. 18,33,36 In this study, according to Fig. 4, since there is no overlap between the MIP-CDs fluorescence spectra and the UV-Vis spectra of the target molecule (propranolol), the energy transfer mechanism is not possible.…”
In this article, a new optical sensor was developed using a molecularly imprinted polymers layer coated with new green carbon dots (CDs) for the determination of propranolol. First, the CDs were synthesized for the first time from Cedrus plant through the hydrothermal method. Then, a nanolayer molecularly imprinted polymer (MIP) was applied on the CDs (MIP-CDs) in the presence of propranolol as a template using a reverse microemulsion technique. Afterward, propranolol was removed from MIP-CDs nanocomposites using a mixture of ethanol and acetonitrile, and the obtained nanocomposite was used as a fluorescence sensor for propranolol determination. Under the optimal conditions, the sensor response was linear in the range of 0.8 -65.0 nmol L -1 with a detection limit of 0.2 nmol L -1 . The results confirmed that the sensor has some advantages such as cost-effectiveness, rapid response, high sensitivity and selectivity for propranolol determination.
“…The dose-response curve for this system displayed a wide linear range (0â1.2 Ă 10 â6 M) even in the presence of common ionic and molecular interfaces that can be found in biofluids, yielding an LoD of 100â150 Ă 10 -9 M. All results were validated with HPLC, which emphasizes that the assay is not only interesting because it is handheld and requires little instrumentation but also has enough diagnostic relevance. Over the past two years alone, many similar QD-based MIP assays have been developed for various purposes including medical diagnostics [ [216] , [217] , [218] ], food safety [ 219 , 220 ] and environmental screening [ 221 , 222 ]. Fig.…”
Highlights
The review aims to summarize recent commercially interesting innovations in MIP-based sensor design.
In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed.
The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems.
The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.
“…Work is currently underway to develop a sustainable and cleaner chemistry called Green Chemistry. This trend has also led to the manufacture of QDs as described by Shariati et al [135] The synthesis of CDs from hydrothermal treatment of cedar and their application as cores coated with MIP layers for the fluorescent determination of phenobarbital can be considered as an example. The signal was maintained even in the presence of other compounds present in the plasma sample such as ions, amino acids and other biomolecules, confirming that there is no cross-reactivity or competition for binding sites.…”
We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.
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