In order to reduce the emissions of pollutants from diesel exhaust, a kind of exhaust purification technology by the combination of non-thermal plasma (NTP) with Nano-CeO 2 supported on the micro-wood fiber filter is proposed, and a simulation test bench is designed to test the influence factors of purification efficiency. It can be seen from the simulation experiments, the purification efficiency for particulate matter (PM) and NO x can be enhanced from 37 and 28% to 53 and 38% when the content of Nano-CeO 2 is from 0 to 16.92 wt%. The test results also show that the purification efficiency of PM and NO x increases with the rising of temperature between 40 and 160 C. Furthermore, when the mass of PM is no more than 30 mg, the purification efficiency of PM and NO x increases with the rising of PM mass. At last, the experiment shows that when the input voltage is between 6 and 12 kV, the corresponding purification efficiency increases with the rising of voltage. Temperature 160 C, catalyst 16.92 wt%, input voltage 12 kV, and PM 30 mg are the best experimental conditions for this study, in which the corresponding purification of PM and NO x is 66 and 53%, respectively. This can provide an experimental basis for the practical application of NTP and wood fiber filters in the field of exhaust gas purification.