In this research, a case study is explored and examined by choosing a construction project. The budget of this project is calculated and analyzed using two methods. A comparison between these two approaches is conducted in terms of performance, effort, accuracy, and cost of calculation. These two techniques are manual quantity surveying and numerical project take-off depending on BIM technology (REVIT software package). The quantity take-off of steel, concrete, and other vital architectural elements and structural building components was considered. The results of this work revealed that there are perfect agreements between the traditional cost-estimation method and the ANSYS numerical calculation associated with all construction elements and components, indicating that BIM technology can offer a reliable solution to determine the construction project cost with higher complexity and components. Furthermore, it was found that the use of REVIT software has cut a significant number of human errors that occurred during the estimation process and quantity take-off for the project cost. In addition, the results of the manual and numerical methods of cost calculation indicated that the REVIT software had saved much time and effort needed for engineers to estimate the budget related to this challenging case study that represents a hospital building with various structural components.