Application of conventional and high-pressure extraction techniques for the isolation of bioactive compounds from the aerial part of hemp (Cannabis sativa L.) assortment Helena

Drinić, Zorica; Vladić, Jelena; Koren, Anamarija; Zeremski, Tijana; Stojanov, Nadežda; Tomić, Milan; Vidović, Senka

doi:10.1016/j.indcrop.2021.113908

Cited by 20 publications

(12 citation statements)

References 58 publications

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“…Te C. sativa threshing ethanolic extract contained a high level of total polyphenols (TP) and total favonoids (TF), 8.43 ± 0.28 mg GAE/g dw and 3.13 ± 0.43 mg GAE/g dw, respectively. In agreement with a previous study reporting similar levels of TP and TF content of aerial parts of mature hemp that ranged from 5.85 to 9.25 mg GAE/g dw and from 1.83 to 5.21 mg CE/g dw, respectively [31].…”

Section: Discussionsupporting

confidence: 93%

Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent

Mahou

Chda

Es‐Safi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Introduction. Ethanolic fraction of Moroccan Cannabis sativa threshing residues (EFCS) was evaluated for its vasorelaxant activity. The current work aims to identify the active metabolites in the ethanolic fraction of the EFCS and illustrate their mechanism of action. Methods. Free radical scavenging capacity of EFCS was assessed using DPPH method. The EFCS vasodilation activities in phenylephrine-precontracted isolated rat mesenteric arterial beds were investigated in presence of L-NAME (nitric oxide synthase inhibitor), indomethacin (cyclooxygenase inhibitor), potassium channel blockers (namely tetraetylamonium, barium chloride, and glibenclamide), and atropine. Nitric oxide vascular release was measured by electron paramagnetic resonance (EPR) using a spin trap in rat aortic rings. Results. EFCS induced dose-dependent vasorelaxation on mesenteric vascular bed. Incubation of the preparations with L-NAME, ODQ (a soluble guanylyl cyclase inhibitor), or potassium channel blockers reduced the fall of perfusion pressure caused by EFCS. Endothelial denudation or atropine abolished the EFCS’s vasorelaxant effect, suggesting involvement of muscarinic receptors and endothelium-relaxing factors. The extract induced nitric oxide release in aortic rings in a similar manner as acetylcholine suggesting an effect of EFCS on the muscarinic receptor and the conductance arteries. Chemical investigation of EFCS identified potential active components namely apigenin and derivatives of luteolin skeleton and also additional components such as neophytadiene, squalene, and β-sitosterol. In conclusion, the vasorelaxant effect of EFCS on rat mesenteric arterial bed, which is dependent of muscarinic receptor activation, nitric oxide, and EDHF, can account for potential therapeutic use against high blood pressure related cardiovascular diseases.

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Section: Discussionsupporting

confidence: 93%

Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent

Mahou

Chda

Es‐Safi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…In addition, high-pressure technologies, such as pressurized liquid extraction (PLE) and SFE, also have been largely employed. PLE was used largely to obtain cannabinoids [47][48][49]; meanwhile, SFE is the most applied method to obtain oil [50][51][52][53][54], cannabinoids [55][56][57][58][59][60][61][62], volatile compounds [59,63,64], and phenolic compounds [46].…”

Section: Supercritical Fluid Extraction (Sfe)mentioning

confidence: 99%

Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications

et al. 2023

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Supercritical carbon dioxide (CO2) extraction techniques meet all-new consumer market demands for health-promoting phytochemical compound-rich extracts produced from green and sustainable technology. In this regard, this review is dedicated to discussing is the promise of integrating high-pressure CO2 technologies into the Cannabis sativa L. processing chain to valorize its valuable pharmaceutical properties and food biomass. To do this, the cannabis plant, cannabinoids, and endocannabinoid system were reviewed to understand their therapeutic and side effects. The supercritical fluid extraction (SFE) technique was presented as a smart alternative to producing cannabis bioproducts. The impact of SFE operating conditions on cannabis compound extraction was examined for aerial parts (inflorescences, stems, and leaves), seeds, and byproducts. Furthermore, the opportunities of using non-thermal supercritical CO2 processing on cannabis biomass were addressed for industrial hemp valorization, focusing on its biorefinery to simultaneously produce cannabidiol and new ingredients for food applications as plant-based products.

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“…Differences in the genotypic characteristics of cannabis species affect the overall yield but less on the content of THC and CBD in individual species (Izzo et al, 2020;Janatová et al, 2018). Some studies have shown that vaporizers to extract cannabinoids yield products with fewer harmful components involved in smoke (Drinić et al, 2021;Fine & Rosenfeld, 2013).…”

Section: Relationship Of Marijuana Use To Mortalitymentioning

confidence: 99%

“…When evaluating the extraction solvents used, the researchers indicated a mixture of polar and nonpolar solvents. Some studies have shown that vaporizers to extract cannabinoids yield products with fewer harmful components involved in smoke (Drinić et al., 2021; Fine & Rosenfeld, 2013).…”

Section: Cannabinoidsmentioning

confidence: 99%

Are cannabidiol (CBD) levels in consumer food products well tested?—A review

Siddiqui,

Fidan,

Stankov

et al. 2023

Food Frontiers

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There are differing views on cannabis and phytocannabinoid usage in diverse domains of application. This review explores the advantages and drawbacks of using cannabis and phytocannabinoids, including their effects on human health, in addition to highlighting the need for precise and repeatable analytical methods for quantifying controlled phytocannabinoids in consumer cannabidiol (CBD) products and foods. The composition and characteristics of the phytochemicals found in cannabis, the advantages and disadvantages of controlled and uncontrolled phytocannabinoids, and the need for regulation and standardization in the use of cannabis and products containing phytocannabinoids are all covered in this review of the pertinent literature. Cannabinoids used illegally can have negative consequences, but controlled phytocannabinoids found in consumer CBD products are relatively safe and unlikely to cause any adverse effects. It is necessary to restrict the amount of CBD in foods and consumer products in order to ensure safety. To measure the amount of restricted phytocannabinoids in these products, accurate analytical techniques are also required. In order to increase the use of cannabis among consumers, more research is needed to improve our understanding of the bioavailability and metabolic pathways of these compounds. Furthermore, consumers want clear and uniform federal rules governing the amount of CBD in food products in order to ensure correct dosing. To promote safe and responsible use, cannabis and phytocannabinoids must be carefully considered, regulated, and standardized. It is necessary for consumers to have clear, consistent standards governing the percentage of CBD in their food products. As a result, they would know the exact amount of CBD in their products.

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Application of conventional and high-pressure extraction techniques for the isolation of bioactive compounds from the aerial part of hemp (Cannabis sativa L.) assortment Helena

Cited by 20 publications

References 58 publications

Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent

Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent

Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications

Are cannabidiol (CBD) levels in consumer food products well tested?—A review

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