Application of deep eutectic solvent-based extraction coupled with an S-CQD fluorescent sensor for the determination of pirimicarb in cereals

Jing, Xu; Wu, Jing; Guo, Luyao; Zheng, Xiaojiao; Wang, Xiaowen; Wang, Shuo

doi:10.1016/j.foodchem.2021.131360

Cited by 15 publications

(1 citation statement)

References 27 publications

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“…Pirimicarb is a widely employed carbamate insecticide in apple orchards and in general, is considered to be a selective aphidicide [ 6 ]. Despite photodegradation and microbial degradation of pirimicarb, it has been proven [ 7 ] that pirimicarb still persists in some environmental matrices as a residue, notably in food [ 8 , 9 , 10 ]. Therefore, for this compound, food and water contamination present as the main ways to affect humans; however a video imaging technique has revealed vast deposition of pirimicarb on the bodies of greenhouse chrysanthemum workers [ 11 ], which is considered as direct exposure to pesticide nuisance.…”

Section: Introductionmentioning

confidence: 99%

Pirimicarb Induction of Behavioral Disorders and of Neurological and Reproductive Toxicities in Male Rats: Euphoric and Preventive Effects of Ephedra alata Monjauzeana

et al. 2023

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Carbamate pesticides are a risk to human well-being, and pirimicarb is the most widely employed carbamate insecticide. This ongoing investigation aimed to reveal its toxicity on neurobehavioral and reproductive function. The study was carried out on male Wistar rats by assessment of behavioral changes via experiments, such as the forced swim test and the elevated plus maze; determination of oxidative stress (checking parameters such as catalase activity, etc.); measurement of cortisol and testosterone serum titers, and IL-1β levels in the plasma and brain; and evaluation of histopathological lesions that induced pirimicarb after 28 days of gavage, specifically in the brain and testis. Traces of pirimicarb were analyzed in tissue extracts using LCMS/MS. At the same time, the beneficial and protective effect of EamCE (Ephedra alata monjauzeana Crude Extract) were tested. The outcomes showed considerable anxiety and depressive status, with an evident increase in cortisol and IL-1β titers and an important decrease in oxidative enzymes and testosterone. Significant histological lesions were also recorded. In addition, the LCMS/MS analysis affirmed the accumulation of pirimicarb in organ tissue from rats force-fed with pirimicarb. Conversely, EamCE demonstrated outstanding potential as a preventive treatment, restoring cognitive and physical performance, boosting fertility, enhancing antioxidant and anti-inflammatory activities and preserving tissue integrity. We concluded that pirimicarb has critical deleterious impacts on health, affecting the neuroimmune-endocrine axis, and EamCE has a general euphoric and preventive effect.

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