Application of Dimethylaminomethylene Ketone in Heterocycles Synthesis: Synthesis of 2‐(Isoxazolo, Pyrazolo, and Pyrimido) Substituted Analogs of 1,4‐Benzodiazepin‐5‐carboxamides Linked through an Oxyphenyl Bridge

Abstract

Versatility of dimethylaminomethylene ketone derivative of 2‐(4′‐acetyl)‐phenoxyl‐5‐carboxamido‐1,4‐benzodiazepin‐5‐(4′‐methylpiperazinyl)‐carboxamide (6) was explored to provide an easy one‐pot access to its 2‐(isoxazolo, pyrazolo, and pyrimido) substituted analogs 8, 9, 10, 11, 12, and 13, respectively.

Synthesis of New 3‐(Furan‐2‐yl)‐Substituted Dibenzo‐Diazepin‐1‐one Derivatives

“…Some researchers are interested in the preparation methods of benzodiazepine derivatives, including the catalyst method , solid state reaction method , and microwave radiation method . Others focused on fusing benzodiazepines with other heterocyclic systems, such as pyrrolo‐, triazole‐, isoxazolo‐, pyrazolo‐, or oxazino‐benzodiazepines . They looked for strengthening or inducing new pharmacological activities for those benzodiazepines .…”