Application of DNA-Nanosensor for Environmental Monitoring: Recent Advances and Perspectives

Kumar, Vinay; Guleria, Praveen

doi:10.1007/s40726-020-00165-1

Cited by 29 publications

(6 citation statements)

References 140 publications

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“…Two years after, Shafiee et al (2020) leveraged the unique properties of DNA, such as molecular programmability and nanoscale controllability, which led to the creation of a complementary DNA strand for miR-106a [87]. DNA, renowned for its organic ligand characteristics, proved to be an excellent choice, being widely acknowledged as a fundamental building block for novel nanomaterials [27]. In both cases, despite the improved capabilities, this analysis seemed to necessitate more time than the optimal duration expected for an ideal biosensor.…”

Section: Rna Nanobiosensors In Gcmentioning

confidence: 99%

“…As we examine through this review, these demonstrate high sensitivity and specificity in the early detection of GC biomarkers. DNA is an excellent building block for making nanomaterials, but most nanobiosensors use DNA as a recognition element and different other nanomaterials as transducing components [27]. In contrast, RNA nanotechnology uses single-stranded oligonucleotides and is considered by some, the gold standard for preventing various malignant tumors through focused diagnosis [28].…”

Section: Introductionmentioning

confidence: 99%

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Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

Avanu,

Ciubotariu,

Dodi

2024

Chemosensors

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Gastric cancer (GC) remains a significant global health challenge, with late-stage diagnosis impacting treatment options and decreased survival rates. To address this, there has been a growing interest in the development of innovative screening and diagnostic methods. Over the past 20 years, nanobiosensors have undergone multiple iterations and unveiled remarkable features that pledge to reshape patient care. Despite the excitement over the plethora of ground-breaking advancements for cancer detection, use-ready samples and streamlined healthcare information monitoring and usage, this technology is still awaiting entry into clinical trials, urging a closer gaze within the medical community. Oligonucleotide-based biosensors, leveraging DNA or RNA’s long-term storage of information, offer great specificity and sensitivity, as described throughout this paper. Consequently, this renders them as an ideal choice for revolutionizing GC diagnosis and facilitating early intervention. The aim of this review is to provide an overview of this cutting-edge, invaluable technology and its limitations across various aspects.

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Section: Rna Nanobiosensors In Gcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

Avanu,

Ciubotariu,

Dodi

2024

Chemosensors

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“…Nanomaterials, such as carbon nanotubes, graphene, or quantum dots, are often used as sensing elements due to their unique electrical, optical, or catalytic properties. These nanosensors enable real-time and on-site monitoring of environmental contaminants, providing valuable data for pollution assessment and control (Kumar et al 2020).…”

Section: Application Of Nanotechnology In Environmental Monitoringmentioning

confidence: 99%

A Review of the Application of Nanotechnology in Different Spheres of Life Sciences

Basu,

Das,

Kundu

2023

Int. J. Res. Publ. Rev.

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Nanotechnology has emerged as a groundbreaking field with vast potential for revolutionizing various domains of life sciences. This review paper aims to provide a comprehensive overview of the applications of nanotechnology across diverse spheres of life sciences. It encompasses the remarkable advancements in nanomaterial synthesis, characterization, and manipulation, along with their integration into targeted drug delivery systems, diagnostic techniques, tissue engineering, and environmental monitoring. The paper begins by discussing the fundamental principles and techniques employed in nanomaterial synthesis, including top-down and bottom-up approaches. It explores the synthesis of various nanomaterials such as nanoparticles, nanotubes, and nanocomposites, highlighting their unique physicochemical properties that enable precise control over size, shape, and surface functionality. Subsequently, the review delves into the role of nanotechnology in drug delivery systems, elucidating the challenges associated with conventional drug delivery methods and the potential solutions offered by nanoscale carriers. It explores the design and fabrication of nanoparticle-based drug delivery systems capable of enhancing therapeutic efficacy, minimizing side effects, and overcoming biological barriers. Moreover, the review encompasses the utilization of nanotechnology in diagnostics, shedding light on the development of nanosensors, biosensors, and imaging agents that enable sensitive and specific detection of biomarkers for disease diagnosis. The integration of nanomaterials with various diagnostic techniques such as polymerase chain reaction (PCR), fluorescence microscopy, and magnetic resonance imaging (MRI) is also explored. Furthermore, the paper discusses the applications of nanotechnology in tissue engineering, highlighting the use of nanomaterials as scaffolds for cell growth, differentiation, and regeneration. It explores the incorporation of nanofibers, nanogels, and nanocomposites into tissue engineering constructs, enabling the development of functional and biomimetic tissues for transplantation and regenerative medicine. Lastly, the review touches upon the environmental applications of nanotechnology, emphasizing the development of nanosensors for monitoring pollutants, water purification, and remediation of contaminated sites. It examines the use of nanomaterials for efficient adsorption, catalysis, and sensing of environmental pollutants, offering potential solutions to address pressing environmental challenges.In summary, this review paper provides a comprehensive overview of the wide-ranging applications of nanotechnology in life sciences. By harnessing the unique properties of nanomaterials, researchers have made significant strides in targeted drug delivery, diagnostics, tissue engineering, and environmental monitoring. The remarkable advancements discussed in this paper highlight the transformative potential of nanotechnology and pave the way for future innovations in the field of life sciences.

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“…Electrochemical DNA biosensors are highly advantageous for the detection of particular ssDNA molecules due to their fast response time, inexpensive instrumentation and miniaturization potential [ 12 ]. Due to these advantages, DNA biosensors have been used so far in various applications, such as clinical diagnostics [ 13 ], drug interactions [ 14 ] and detection [ 15 ], and environmental monitoring [ 16 ]. The development of simple and effective electrochemical methods is of high interest in nucleic acid detection [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection Platform Based on RGO Functionalized with Diazonium Salt for DNA Hybridization

2022

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In this paper, we propose an improved electrochemical platform based on graphene for the detection of DNA hybridization. Commercial screen-printed carbon electrodes (SPCEs) were used for this purpose due to their ease of functionalization and miniaturization opportunities. SPCEs were modified with reduced graphene oxide (RGO), offering a suitable surface for further functionalization. Therefore, aryl-carboxyl groups were integrated onto RGO-modified electrodes by electrochemical reduction of the corresponding diazonium salt to provide enough reaction sites for the covalent immobilization of amino-modified DNA probes. Our final goal was to determine the optimum conditions needed to fabricate a simple, label-free RGO-based electrochemical platform to detect the hybridization between two complementary single-stranded DNA molecules. Each modification step in the fabrication process was monitored by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) using [Fe(CN)6]3−/4− as a redox reporter. Although, the diazonium electrografted layer displayed the expected blocking effect of the charge transfer, the next steps in the modification procedure resulted in enhanced electron transfer properties of the electrode interface. We suggest that the improvement in the charge transfer after the DNA hybridization process could be exploited as a prospective sensing feature. The morphological and structural characterization of the modified electrodes performed by scanning electron microscopy (SEM) and Raman spectroscopy, respectively, were used to validate different modification steps in the platform fabrication process.

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Application of DNA-Nanosensor for Environmental Monitoring: Recent Advances and Perspectives

Cited by 29 publications

References 140 publications

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

A Review of the Application of Nanotechnology in Different Spheres of Life Sciences

Electrochemical Detection Platform Based on RGO Functionalized with Diazonium Salt for DNA Hybridization

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