Application of eco‐friendly disposable pencil graphite sensor for electrochemical evaluation and determination of podophyllotoxin using in cancer treatment

Abstract

A sensitive, simple and selective voltammetric method was developed for the quantification of plant‐derived podophyllotoxin, which is included in antineoplastic drugs, using a disposable pencil graphite electrode. Using the square‐wave voltammetry technique, podophyllotoxin gave a very good voltammetric response at +1.24 V (vs. Ag/AgCl) potential (at 0.0 V and after 60 s pre‐concentration) in Britton Robinson (pH 4.0) media. This procedure was used to detection the compound in the concentration range of 12.4–299.5 nM with a limit of detection to 2.62 nM (1.08 μg L−1). The proposed method has been successfully applied to human urine samples.