Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems

Sarvarian, Parisa; Samadi, Parisa; Gholipour, Elham; Asenjan, Karim Shams; Hojjat‐Farsangi, Mohammad; Motavalli, Roza; Khiavi, Farhad Motavalli; Yousefi, Mehdi

doi:10.1080/08820139.2021.1891094

Cited by 38 publications

(25 citation statements)

References 77 publications

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“…Extracellular vesicles fall into two broad categories: ectosomes (size: 100 to 500 nm) and exosomes (size: 30 to 150 nm) (20)(21)(22)(23). PELNs are a kind of extracellular vesicles ranging in size from 50 to 500 nm derived from plants (15). Besides animal vesicles, PELNs have a complex content of small RNAs, proteins, lipids, and other metabolites.…”

Section: Pelnsmentioning

confidence: 99%

“…Halperin et al first discovered evidence of the existence of PELNs in carrot cell cultures in 1967 (14). PELNs (50-500 nm in diameter) contain mRNAs, microRNAs (miRNAs), bioactive lipids, and proteins (15,16). Compared to artificial nanocarriers, PELNs do not exert cytotoxicity on human cells (15).…”

Section: Introductionmentioning

confidence: 99%

“…PELNs (50-500 nm in diameter) contain mRNAs, microRNAs (miRNAs), bioactive lipids, and proteins (15,16). Compared to artificial nanocarriers, PELNs do not exert cytotoxicity on human cells (15). PELNs lipid bilayer contains high contents of glycolipids and phospholipids but lacks cholesterol, which indicates the potential application of PELNs as a tissue targeting drug carrier (16).…”

Section: Introductionmentioning

confidence: 99%

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The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

et al. 2022

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Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, it is urgent to explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant and bone protective effects to periodontitis and most of these natural products are safe and cost-effective. Among these, the plant-derived exosome-like nanoparticles (PELNs), a type of natural nanocarriers repleted with lipids, proteins, RNAs, and other active molecules, show the ability to enter mammalian cells and regulate cellular activities. Reports from the literature indicate the great potential of PELNs in the regulation of immune functions, inflammation, microbiome, and tissue regeneration. Moreover, PELNs can also be used as drug carriers to enhance drug stability and cellular uptake in vivo. Since regulation of immune function, inflammation, microbiome, and tissue regeneration are the key phenomena usually targeted during periodontitis treatment, the PELNs hold the promising potential for periodontitis treatment. This review summarizes the recent advances in PELNs-related research that are related to the treatment of periodontitis and regeneration of periodontitis-destructed tissues and the underlying mechanisms. We also discuss the existing challenges and prospects of the application of PELNs-based therapeutic approaches for periodontitis treatment.

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Section: Pelnsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

et al. 2022

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“…Exosome-like nanoparticles isolated from a variety of plant sources have the potential to be used as therapeutic drug delivery vehicles for the treatment of certain diseases [67,68]. Edible plant exosomes derived from ginger, lemon, grapefruit, grape, broccoli, and carrot would be suitable for the treatment of inflammatory diseases due to their anti-inflammatory properties [69][70][71][72][73].…”

Section: Natural Exosome-like Nanoparticlesmentioning

confidence: 99%

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Kučuk

Primožič

Knez

et al. 2021

IJMS

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Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety of therapeutic applications due to their unique characteristics, especially due to the ineffectiveness and cytotoxicity of some existing therapies and synthetic therapeutic nanocarriers. They are highly promising as carriers of drugs, genes, and other therapeutic agents that can be incorporated into their interior or onto their surface through various modification techniques to improve their targeting abilities. In addition, they are biocompatible, safe, and stable. The review focuses on different types of exosomes and methods of their preparation, including the incorporation of different kinds of cargo, especially for drug delivery purposes. In particular, their importance and effectiveness as delivery vehicles of various therapeutic agents for a variety of therapeutic applications, including different diseases and disorders such as cancer treatment, cardiovascular and neurodegenerative diseases, are emphasized. Administration routes of exosomes into the body are also included. A novelty in the article is the emphasis on global companies that are already successfully developing and testing such therapeutic biomaterials, with a focus on the most influential ones. Moreover, a comparison of the advantages and disadvantages of the various methods of exosome production is summarized for the first time.

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“…Fortunately, ongoing researches demonstrated that plants-derived nanovesicles (PDNVs) have similar properties to EVs [ 22 ]. PDNVs have various advantages, including sustainability, natural availability, renewability, and cost efficiency [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

et al. 2021

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Background Cancer is one of the devastating diseases in the world. The development of nanocarrier provides a promising perspective for improving cancer therapeutic efficacy. However, the issues with potential toxicity, quantity production, and excessive costs limit their further applications in clinical practice. Results Herein, we proposed a nanocarrier obtained from aloe with stability and leak-proofness. We isolated nanovesicles from the gel and rind of aloe (gADNVs and rADNVs) with higher quality and yield by controlling the final centrifugation time within 20 min, and modulating the viscosity at 2.98 mPa S and 1.57 mPa S respectively. The gADNVs showed great structure and storage stability, antioxidant and antidetergent capacity. They could be efficiently taken up by melanoma cells, and with no toxicity in vitro or in vivo. Indocyanine green (ICG) loaded in gADNVs (ICG/gADNVs) showed great stability in both heating system and in serum, and its retention rate exceeded 90% after 30 days stored in gADNVs. ICG/gADNVs stored 30 days could still effectively damage melanoma cells and inhibit melanoma growth, outperforming free ICG and ICG liposomes. Interestingly, gADNVs showed prominent penetrability to mice skin which might be beneficial to noninvasive transdermal administration. Conclusions Our research was designed to simplify the preparation of drug carrier, and reduce production cost, which provided an alternative for the development of economic and safe drug delivery system. Graphical Abstract

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Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems

Cited by 38 publications

References 77 publications

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

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