Application of enzymatic probe sonication extraction for the determination of selected veterinary antibiotics and their main metabolites in fish and mussel samples

Fernández‐Torres, Rut; López, Miguel Ángel; Consentino, M. Olías; Mochón, M. Callejón; Pérez-Bernal, Juan Luis

doi:10.1016/j.aca.2010.07.026

Cited by 24 publications

(8 citation statements)

References 25 publications

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“…The concentration in other parts ranged from 716.2 to 906.2 ng/g, 75.25e79.12 ng/g and 107.7e119.4 ng/g for diclofenac, sulfamethoxazole and phenytoin respectively. By comparison, the highest concentration of sulfamethoxazole in our study is higher than those (0.95 ng/g) reported in the tissue of hake fish in Spain (Fernandez-Torres et al, 2010) and in a study reported by Li et al (2012b) in North China (2.15 ng/g) while in a study from Laizhou Bay, North China the concentration of sulfamethoxazole (40e110 ng/g) in some fish organs were similar and other were lower compared to our study (Liu et al, 2018).…”

Section: Pharmaceutical Compoundscontrasting

confidence: 73%

Occurrences, levels and risk assessment studies of emerging pollutants (pharmaceuticals, perfluoroalkyl and endocrine disrupting compounds) in fish samples from Kalk Bay harbour, South Africa

Ojemaye

Petrik

2019

Environmental Pollution

136

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A comprehensive analysis of 15 target chemical compounds (pharmaceuticals and personal care product, perfluoroalkyl compounds and industrial chemicals) were carried out to determine their concentrations in selected commercially exploited, wild caught small and medium sized pelagic fish species and their organs (Thyrsites atun (snoek), Sarda orientalis (bonito), Pachymetopon blochii (panga) and Pterogymnus laniarius (hottentot)) obtained from Kalk Bay harbour, Cape Town. Solid phase extraction (SPE) method based on Oasis HLB cartridges were used to concentrate and clean-up the samples. Liquid chromatographyemass spectrometry analysis of these chemical compounds revealed the simultaneous presence of at least 12 compounds in different parts of the selected fish species in nanogram-per-gram dry weight (ng/g dw) concentrations. The results revealed that perfluorodecanoic acid, perfluorononanoic acid and perfluoroheptanoic acid were the most predominant among the perfluorinated compounds and ranged between: (20.13e179.2 ng/g), (21.22e114.0 ng/g) and (40.06e138.3 ng/g). Also, diclofenac had the highest concentration in these edible fish species out of all the pharmaceuticals detected (range: 551.8e1812 ng/g). The risk assessment values were above 0.5 and 1.0 for acute and chronic risk respectively which shows that these chemicals have a high health risk to the pelagic fish, aquatic organisms and to humans who consume them. Therefore, there is an urgent need for a precautionary approach and the adequate regulation of the use and disposal of synthetic chemicals that persist in aquatic/marine environment in this province and other parts of South Africa, to prevent impacts on the sustainability of our marine environment, livelihood and lives.

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Section: Pharmaceutical Compoundscontrasting

confidence: 73%

Occurrences, levels and risk assessment studies of emerging pollutants (pharmaceuticals, perfluoroalkyl and endocrine disrupting compounds) in fish samples from Kalk Bay harbour, South Africa

Ojemaye

Petrik

2019

Environmental Pollution

136

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“…It is important to remark that the presence of these drugs in animal tissues can have undesirable effects on consumer health such as allergies; however, the main problem related with the presence of this antimicrobial compounds in fish tissues is the non-controlled ingestion of antibiotics, possibly inducing resistance in bacterial strains [4,66,94,95].…”

Section: Bioaccumulation and Bacteria Resistance Genesmentioning

confidence: 99%

“…Over the last decades, the occurrence of antibiotics in tissues of aquatic organisms has raised the interest of different organisations around the globe, particularly the FDA in USA. It has been reported that continuous exposure to these pharmaceutical compounds may result in accumulation of the parent compound, their metabolites or both in tissues of aquatic organisms [95].…”

Section: Bioaccumulation and Bacteria Resistance Genesmentioning

confidence: 99%

See 1 more Smart Citation

Amoxicillin in the Aquatic Environment, Its Fate and Environmental Risk

Elizalde-Velázquez¹,

Gómez-Oliván²,

Galár-Martínez³

et al. 2016

Environmental Health Risk - Hazardous Factors to Living Species

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Amoxicillin is a broad-spectrum antibiotic widely used for treating both human and animal diseases, and it belongs to a group that are excreted unchanged within urine and faeces; therefore, it is possible to find traces of this drug or its degradation products in environmental water bodies. In water, it is rapidly degraded by biotic and abiotic factors, yielding different intermediate products; these are suspected of being more resistant to degradation, and potentially more toxic, than the parent compound. In the water bodies, these compounds may produce toxic effects on the aquatic organisms from different trophic levels and produce an ecological imbalance. Amoxicillin may bioaccumulate in fish muscle tissues, with the possibility of the occurrence of these drugs in food, leading to a passive consumption of this antibiotic resulting in undesirable effects on consumer health such as immunoallergic responses. However, the main problem related with the presence of this antimicrobial compounds in fish tissues is the possibility of inducing bacterial resistance genes. At present, the available scientific knowledge is less than what is needed to fully assess the risks that amoxicillin pose to the environment, and it is still necessary to conduct large amount of research works before a thorough understanding of this severe environmental issue.

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“…For the analysis of pharmaceuticals in biotic samples, extraction techniques such as soxhlet extraction, sonication [16], microwave assisted extraction (MAE) [17] and pressurized liquid extraction (PLE) [18,19] have been employed. However, the disadvantages of these sample preparation methods include the use of large amounts of organic solvent and the time required for the preparation of each sample.…”

Section: Introductionmentioning

confidence: 99%

MicroQuEChERS–nanoliquid chromatography–nanospray–tandem mass spectrometry for the detection and quantification of trace pharmaceuticals in benthic invertebrates

Berlioz‐Barbier

Baudot

Wiest

et al. 2015

Talanta

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Application of enzymatic probe sonication extraction for the determination of selected veterinary antibiotics and their main metabolites in fish and mussel samples

Cited by 24 publications

References 25 publications

Occurrences, levels and risk assessment studies of emerging pollutants (pharmaceuticals, perfluoroalkyl and endocrine disrupting compounds) in fish samples from Kalk Bay harbour, South Africa

Occurrences, levels and risk assessment studies of emerging pollutants (pharmaceuticals, perfluoroalkyl and endocrine disrupting compounds) in fish samples from Kalk Bay harbour, South Africa

Amoxicillin in the Aquatic Environment, Its Fate and Environmental Risk

MicroQuEChERS–nanoliquid chromatography–nanospray–tandem mass spectrometry for the detection and quantification of trace pharmaceuticals in benthic invertebrates

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