Application of exosomes as nanocarriers in cancer therapy

Hu, Jiawei; Zhu, Junfei; Chai, Jingjing; Zhao, Yudie; Luan, Jiajie; Wang, Yan

doi:10.1039/d3tb01991h

Cited by 2 publications

(1 citation statement)

References 163 publications

(184 reference statements)

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“…Therefore, there is an urgent need to develop a device for preparing uniform and purified exosomes. 120 Thirdly, modifying and loading exosomes with small-molecule cargoes can enhance their affinity and lethality towards tumor cells. However, the loading efficiency of engineered exosomes is generally low, possibly due to the presence of other proteins and cargoes.…”

Section: The Challenges Of Exosomes From Car-t Cells In Clinical Appl...mentioning

confidence: 99%

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Hu,

Yang,

Wang

et al. 2024

IJN

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Adoptive T cells immunotherapy, specifically chimeric antigen receptor T cells (CAR-T), has shown promising therapeutic efficacy in the treatment of hematologic malignancies. As extensive research on CAR-T therapies has been conducted, various challenges have emerged that significantly hampered their clinical application, including tumor recurrence, CAR-T cell exhaustion, and cytokine release syndrome (CRS). To overcome the hurdles of CAR-T therapy in clinical treatment, cell-free emerging therapies based on exosomes derived from CAR-T cells have been developed as an effective and promising alternative approach. In this review, we present CAR-T cell-based therapies for the treatment of tumors, including the features and benefits of CAR-T therapies, the limitations that exist in this field, and the measures taken to overcome them. Furthermore, we discuss the notable benefits of utilizing exosomes released from CAR-T cells in tumor treatment and anticipate potential issues in clinical trials. Lastly, drawing from previous research on exosomes from CAR-T cells and the characteristics of exosomes, we propose strategies to overcome these restrictions. Additionally, the review discusses the plight in large-scale preparation of exosome and provides potential solutions for future clinical applications.

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Section: The Challenges Of Exosomes From Car-t Cells In Clinical Appl...mentioning

confidence: 99%