Application of Factorial Design in the Premixing Operation of Diltiazem Timed-Release Pellets

Kumaravelrajan, R.; Raj, V. Mohan; Thirumaran, M.; Suba, V.

doi:10.36468/pharmaceutical-sciences.932

Cited by 2 publications

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“…For evaluation, the particle size distribution was determined by using vibration sieve shaker (ERWEKA, AR-402) set with sieve number 20-120; through which granules were passed (Kumaravelrajan et al, 2022). The percentage retained on each sieve and mean particle size were determined.…”

Section: Pre-compression Evaluation Of Granules Blendmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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The purpose of the current study was to develop stable effervescent-tablets without controlling area relativehumidity; temperature and no requirement of special packaging. Current 3 2 factorial-design experimental studies were conducted in the Research Laboratory of Pharmaceutics, Hamdard University. Duration of study is from December-2021 to November-2022. Various paracetamol based effervescent formulations (F1-F9) were prepared with different molarratio of citric-acid anhydrous and sodium-bicarbonate as independent variables. Design-Expert ® software was used to graphically express the influence of each factor. By novel approach; tablets were compressed at ambient temperature and relative-humidity; acid components were kept on one-side and basic ingredients on another side; both sides were separated by an inert-layer. Tablets were kept at accelerated humidity and temperature in normal packing for six months; after six months, F6 formulation was found acceptable based on effervescence-time (120 sec), pH-value (5.5) and other quality criterion. Parameters of assay, effervescence-time, pH-value and carbon-dioxide content were found within the set-limit. Hence; novel approach for developing effervescent formulation by separating acid components at one-side and basic ingredients on another side of tablet through inert-layer is workable under room temperature and humidity. It is expected that commercial production of tablets by this technique may reduce cost of effervescent products and no requirement for special packaging.

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Section: Pre-compression Evaluation Of Granules Blendmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Novel Paediatric Extended Release Mini-Tablets Formulation and Characterization of Lamotrigine by Design of Experiment (DoE)

R.,

D.,

et al. 2024

RJPT

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The mini-tablets formulations have high patient compliances especially paediatrics and geriatrics The present investigation was to develop and compare HPMC K100 M and HPMC K4 M, a combination of processing variables of 32 factorial design factors, in the formulation of 100mg lamotrigine sustained drug release of mini-tablets for paediatric usage. The amount of lamotrigine in each little tablet is 25mg, and they were made using the direct compression method. Dependent variables included drug release and tensile strength. Drug release was sustained for at least 12 hours across all formulations. The drug release was proportional to the HPMC K4M and HPMC K100M concentrations. The dosages of 2, 4, and 6mg were also kept constant. When mini-tablets prepared with combination of polymers (12mg), F8 exhibits a tensile strength of 3.42N/m2 (6mg). Through numerical optimization, HPMC K4M = 11.0mg and HPMC K100 M = 4.50mg were discovered, resulting in 95.4 percent drug release and 3.1 (N/m2) tensile strength. An in vivo study with the optimized formulation in rats showed (AUC 0-t) and (AUMC 0-t) of 1123.4 (h)* (µg/ml) and 3313 h2* (µg/ml) respectively. Cmax and Tmax were 375.0µg/ml and 4 h.

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Application of Factorial Design in the Premixing Operation of Diltiazem Timed-Release Pellets

Cited by 2 publications

References 0 publications

Untitled

Untitled

Novel Paediatric Extended Release Mini-Tablets Formulation and Characterization of Lamotrigine by Design of Experiment (DoE)

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