Application of Factorial Design to Microfiltration Performance

Sousa, Alexandre C.C.; Mateus, Marı́lia

doi:10.1205/026387603762878746

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…The center point is very important because it represents a set of experimental conditions at which three independent replicates were run. The variation between them reflects the variability of all design and it was used to estimate the standard deviation [ 42 ]. All experiments were performed in random order to avoid systematic errors.…”

Section: Methodsmentioning

confidence: 99%

A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles

Wang

Zhao

et al. 2011

IJMS

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In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.

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Section: Methodsmentioning

confidence: 99%