Application of femtosecond laser mass spectrometry to the analysis of volatile organic compounds

Liu, Min; Wu, Chengyin; Wu, Zhifeng; Yang, Hong; Gong, Qihuang; Huang, Wei; Zhu, Tong

doi:10.1016/j.jasms.2010.02.020

Cited by 8 publications

(6 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 Non-resonant ionization using femtosecond lasers has also been considered for analysis of organic compounds due to the high ionization efficiency and low molecular fragmentation. [28][29][30][31] In the tunneling ionization regime there is a strong dependence on the ionization potential which favors ionization of the organic molecules compared with the main gases found in air. However, it is well established that ionization rates for most organic molecules are suppressed compared to atoms with similar ionization potentials.…”

Section: Introductionmentioning

confidence: 99%

Influence of localized surface plasmons on Pauli blocking and optical limiting in graphene under femtosecond pumping

Bongu

Bisht

Namboodiri

et al. 2014

Journal of Applied Physics

View full text Add to dashboard Cite

Many organic molecules have strong absorption bands which can be accessed by ultraviolet short pulse lasers to produce efficient ionization. This resonant multiphoton ionization scheme has already been exploited as an ionization source in time-of-flight mass spectrometers used for environmental trace analysis. In the present work we quantify the ultimate potential of this technique by measuring absolute ion yields produced from the interaction of 267 nm femtosecond laser pulses with the organic molecules indole and toluene, and gases Xe, N 2 and O 2 . Using multiphoton ionization cross sections extracted from these results, we show that the laser pulse parameters required for real-time detection of aromatic molecules at concentrations of one part per trillion in air and a limit of detection of a few attomoles are achievable with presently available commercial laser systems. The potential applications for the analysis of human breath, blood and tissue samples are discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of localized surface plasmons on Pauli blocking and optical limiting in graphene under femtosecond pumping

Bongu

Bisht

Namboodiri

et al. 2014

Journal of Applied Physics

View full text Add to dashboard Cite

show abstract

“…27 In organic vapors, in contrast to solid targets, femtosecond ionization can reduce fragmentation, thus making the identification of mass spectral peaks simpler. 29,30 In contrast to nano-and picosecond pulses, a femtosecond pulse is able to bypass dissociation channels during the excitation processes. 29 Saturation ionization, a condition when all molecules present in the laser focus have been ionized, can occur for organic molecules irradiated with femtosecond laser pulses, which makes the technique highly sensitive and quantitative.…”

mentioning

confidence: 99%

“…29 Saturation ionization, a condition when all molecules present in the laser focus have been ionized, can occur for organic molecules irradiated with femtosecond laser pulses, which makes the technique highly sensitive and quantitative. 30,31 Laser intensity, wavelength, and polarization have all been found to influence the fragmentation of organic molecules. 29,32 Studies of ionization of vapors and gases are likely not directly applicable to ionization of bulk samples or small particles in vacuo because of different physics involved in the processes.…”

mentioning

confidence: 99%

Single-Particle Time-of-Flight Mass Spectrometry Utilizing a Femtosecond Desorption and Ionization Laser

Zawadowicz¹,

Abdelmonem

Mohr

et al. 2015

Anal. Chem.

View full text Add to dashboard Cite

Single-particle time-of-flight mass spectrometry has now been used since the 1990s to determine particle-to-particle variability and internal mixing state. Instruments commonly use 193 nm excimer or 266 nm frequency-quadrupled Nd:YAG lasers to ablate and ionize particles in a single step. We describe the use of a femtosecond laser system (800 nm wavelength, 100 fs pulse duration) in combination with an existing single-particle time-of-flight mass spectrometer. The goal of this project was to determine the suitability of a femtosecond laser for single-particle studies via direct comparison to the excimer laser (193 nm wavelength, ∼10 ns pulse duration) usually used with the instrument. Laser power, frequency, and polarization were varied to determine the effect on mass spectra. Atmospherically relevant materials that are often used in laboratory studies, ammonium nitrate and sodium chloride, were used for the aerosol. Detection of trace amounts of a heavy metal, lead, in an ammonium nitrate matrix was also investigated. The femtosecond ionization had a large air background not present with the 193 nm excimer and produced more multiply charged ions. Overall, we find that femtosecond laser ablation and ionization of aerosol particles is not radically different than that provided by a 193 nm excimer.

show abstract

“…M ass spectrometry has become one of the most important analytical tools in modern scientific studies and industrial applications [1][2][3][4][5][6][7]. The mass to charge ratios obtained from mass spectrometry data can be used to identify and detect modifications of compounds.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Application of APCI Hydrogen–Deuterium Exchange Mass Spectrometry (HDX MS) for the Speciation of Nitrogen Compounds

Acter

Cho

Kim

et al. 2015

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Abstract. A systematic study was performed to investigate the utility of atmospheric pressure chemical ionization hydrogen-deuterium exchange mass spectrometry (APCI HDX MS) to identify the structures of nitrogen-containing aromatic compounds. First, experiments were performed to determine the optimized experimental conditions, with dichloromethane and CH 3 OD found to be good cosolvents for APCI HDX. In addition, a positive correlation between the heated capillary temperature and the observed HDX signal was observed, and it was suggested that the HDX reaction occurred when molecules were contained in the solvent cluster. Second, 20 standard nitrogen-containing compounds were analyzed to investigate whether speciation could be determined based on the different types of ions produced from nitrogencontaining compounds with various functional groups. The number of exchanges occurring within the compounds correlated well with the number of active hydrogen atoms attached to nitrogen, and it was confirmed that APCI HDX MS could be used to determine speciation. The results obtained by APCI HDX MS were combined with the subsequent investigation of the double bond equivalence distribution and indicated that resins of shale oil extract contained mostly pyridine type nitrogen compounds. This study confirmed that APCI HDX MS can be added to previously reported chemical ionization, electrospray ionization, and atmospheric pressure photo ionization-based HDX methods, which can be used for structural elucidation by mass spectrometry.

show abstract

Application of femtosecond laser mass spectrometry to the analysis of volatile organic compounds

Cited by 8 publications

References 37 publications

Influence of localized surface plasmons on Pauli blocking and optical limiting in graphene under femtosecond pumping

Influence of localized surface plasmons on Pauli blocking and optical limiting in graphene under femtosecond pumping

Single-Particle Time-of-Flight Mass Spectrometry Utilizing a Femtosecond Desorption and Ionization Laser

Optimization and Application of APCI Hydrogen–Deuterium Exchange Mass Spectrometry (HDX MS) for the Speciation of Nitrogen Compounds

Contact Info

Product

Resources

About