Application of fingernail samples as a biomarker for human exposure to arsenic-contaminated drinking waters

Shokoohi, Reza; Khazaei, Mohammad; Karami, Manoochehr; Seid‐Mohammadi, Abdolmotaleb; Khazaei, Salman; Torkshavand, Zahra

doi:10.1038/s41598-022-08845-2

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…After chronic ingestion of As, dermatologic lesions have been used as a long-term biomarker of cumulative arsenic exposure [56] (Hughes FM, 2006). A study investigating novel biomarker sampling methods found a significant association between groundwater and fingernail arsenic concentration [57].…”

Section: Arsenicmentioning

confidence: 99%

E-Waste and Metal Contamination in the Environment: Health Effects

Dockrell¹,

Purchase²,

Price³

2023

Trace Metals in the Environment

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It is predicted that electronic waste (e-waste) derived principally from discarded electronic equipment will reach 74 million metric tonnes by 2030. In addition, urbanisation and industrialisation have contributed to metal contamination in the environment. E-waste is often deposed of in low-income countries adversely affecting the health of the working population. The main sources of e-contamination are soil, dust, and food matrices. Drinking water can also be contaminated with heavy metals such as arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) causing a major health concern. Exposure to pollutants present in waste is a common cause of kidney and other diseases primarily amongst children in developing countries. Sensitive monitoring procedures are needed to improve the rate of detection and monitoring of the possible adverse effects on the population exposed to significant quantities of e-waste.

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Section: Arsenicmentioning

confidence: 99%

E-Waste and Metal Contamination in the Environment: Health Effects

Dockrell¹,

Purchase²,

Price³

2023

Trace Metals in the Environment

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“…In addition to the 40 healthy participants from the arsenic-affected rural areas of Iran, 49 fingernail samples were also collected from people who lived in areas where drinking water sources had not been reported to be contaminated with arsenic. It was found that the fingernail arsenic contents in 50 and 4.08% of the samples taken from arsenic-contaminated and reference villages were higher than the typical arsenic values of nails (0.43-1.08 g/g) [63]. The measurement of total arsenic in nails can be performed using the inductively coupled plasma-mass spectrometry (ICP-MS) technique [64].…”

Section: The Fate Of Arsenic: a Comprehensive Overview Of Its Biochem...mentioning

confidence: 99%

Exploring the Interplay between Arsenic and Cutaneous Physiology, Pathology, and Regeneration

Binumon Thankachan,

S. Kamath,

Sasikumar

et al. 2023

Arsenic in the Environment - Sources, Impacts and Remedies

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Arsenic poisoning and groundwater exposure are not regional hazards; we can call them a “silent global hazard.” The victims are not always aware of arsenic-exposed daily life and the use of contaminated groundwater. The World Health Organization (WHO) reported that several countries, including Bangladesh, India, Argentina, Chile, Viet Nam, Cambodia, Pakistan, China, the United States of America (USA), and Mexico, have inorganic arsenic naturally present at high levels in the groundwater. Many of these countries exceeded the typical toxic risk index of arsenic level of the WHO standard of 10 μg L−1. The skin is the primary barrier of the body, and compromising the function of the skin is the beginning of psychosocial and physiological discomfort in humans. Hair loss, skin pigmentation, and skin irritation are the leading psychosocial and physiological facts induced by exposure to arsenic contamination. Like hair, nails are susceptible to external harm from arsenic because they may absorb and accumulate arsenic in vitro. The normal architecture of the skin changes to form epithelial hyperplasia, epidermal erosion, hyperkeratosis, degeneration of skin glands, and gradual replacement of hair shaft to keratinized substance. The extreme condition of arsenic exposure ultimately result in various skin carcinomas and alopecia.

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