Application of first-derivative, ratio derivative spectrophotometry, TLC-densitometry and spectrofluorimetry for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage forms and plasma

Bebawy, Lories I.; Abbas, Samah S.; Fattah, Laila Abdel; Refaat, Heba H.

doi:10.1016/j.farmac.2005.06.009

Cited by 49 publications

(29 citation statements)

References 21 publications

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“…Individually, TELM is estimated by LC-MS (3), LC-tendem MS (4,5). The majority of methods reported are liquid chromatography in which TELM was estimated simultaneously with hydrochlorthiazide (6,7,8), with ramipril (9, 10), with AmLodipine (11). Some three components are also reported along with TELM such as, Column Switching LC with fluorescence detection (12).…”

Section: Preparation Of Laboratory Mixturementioning

confidence: 99%

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Charde¹,

Gupta²,

Chakole³

2012

Int J Pharmceut Chem

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A simple, rapid, precise, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for determination of Telmisartan (TELM) in tablet dosage form was developed and validated. Chromatographic separation was achieved on a 250 × 4.6 mm, 5µ, Waters symmetry column in gradient mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.01): acetonitrile (64:40) was used. The quantitation performed at flow rate of 1.0 mL/min at 230 nm and run time was 12 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness and stability and method can be extended to the analysis of TELM in tablet formulations. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for TELM. The drug undergoes oxidative degradation, thermal degradation and in alkali medium.

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Section: Preparation Of Laboratory Mixturementioning

confidence: 99%

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Charde¹,

Gupta²,

Chakole³

2012

Int J Pharmceut Chem

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“…Thus, the aim of this work was to develop and validate spectrophotometric methods for the determination of PAR and DAS in combination without sample pretreatment. Among various techniques, spectrophotometric methods remain the simplest, fastest and less expensive for the determination of drug mixtures [19][20][21]. Direct UV-absorbance measurement (zero order) is subject to interference from degradation products and/or excipients.…”

Section: Paracetamol (Par); N-acetyl-p-aminophenol;mentioning

confidence: 99%

“…Two methods were developed and validated: first derivative ( 1 D) and first derivative ratio ( 1 DD) spectrophotometric methods to enhance the resolution of overlapping bands. The derivative spectrophotometry can be used for simultaneous determination of many drugs, it is applied by selecting a wavelength where the compound to be determined has a reasonable value while the contribution of the other compound is almost zero [19][20][21].…”

Section: Paracetamol (Par); N-acetyl-p-aminophenol;mentioning

confidence: 99%

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

et al. 2014

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KEYWORDSAccurate, precise and simple spectrophotometric methods have been developed and validated for the determination of paracetamol (PAR) and dantrolene sodium (DAS). Spectrophotometric methods including zero order, first derivative ( 1 D) and derivative ratio methods ( 1 DD) have been developed. The zero order spectrophotometric method was used for the determination of DAS in the range of 1-20 μg/mL by measuring the absorbance at 379 nm where PAR exhibits zero reading. 1 D and 1 DD methods were used for the determination of PAR in the range of 1.5-20.0 μg/mL by measuring the peaks amplitudes at 265.5 nm and 265.0 nm, respectively. The proposed methods were used to determine PAR in binary mixture with DAS in the laboratory prepared mixtures and in pharmaceutical dosage form. The results obtained were statistically evaluated and found to be accurate and precise and can be satisfactorily applied for the quality control analysis of the cited drugs.

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“…The majority of methods reported are liquid chromatography in which Telmisartan was estimated simultaneously with hydrochlorthiazide 6,7,8 , with ramipril 9, 10 , with Amlodipine 11 . Some triple combinations are also reported along with telmisartan such as, Column Switching LC with fluorescence detection 12 .…”

Section: Introductionmentioning

confidence: 99%

Stability-Indicating Rp-HPLC Method for Analysis of Telmisartan in the Dosage Form

Gupta¹,

Charde²,

Charde³

2012

Int J of Adv in Phar Ana

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A simple, rapid, precise, rapid, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for quantitative analysis of Telmisartan (TELM) in pharmaceutical dosage forms. Chromatographic separation of TELM and its degradation products was achieved on a C 18 , 250 × 4.6 mm, 5µ, Waters symmetry column. The flow rate was 1.0 ml/min, the column temperature 40 0 C, and detection was by absorption at 230 nm using a photodiode array detector. The number of theoretical plates and tailing factor for TELM were 8,721 and 1.018, respectively. TELM was exposed to thermal, photolytic, hydrolytic (acidic and alkali), and oxidative stress, and the stressed samples were analyzed by use of the proposed method. Peak homogeneity data for TELM in the chromatograms from the stressed samples, obtained by use of the photodiode-array detector, demonstrated the specificity of the method for analysis of TELM in the presence of the degradation products. The linearity of the method was excellent over the range 10-50 µg/ml. The correlation coefficient was 0.999. Relative standard deviations of peak areas of all measurements were always less than 2%. The proposed method was found to be suitable and accurate for quantitative analysis of TELM and study of its stability.

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Application of first-derivative, ratio derivative spectrophotometry, TLC-densitometry and spectrofluorimetry for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage forms and plasma

Cited by 49 publications

References 21 publications

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Determination of Telmisartan and Forced Degradation Behavior by Rp-HPLC in Tablet Dosage Form

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

Stability-Indicating Rp-HPLC Method for Analysis of Telmisartan in the Dosage Form

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