Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang, Ke; Xu, Xueli; Wei, Qiang; Yang, Qi; Zhao, Jian; Wang, Yuan; Li, Xia; Ji, Kai; Song, Shuliang

doi:10.1177/20406223221076891

Cited by 20 publications

(11 citation statements)

References 104 publications

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“…Consistent with this result, of the two main components we tested, only fucoidan showed significant eGC protection. Designated as HS mimetic [ 32 ], numerous properties with potential for therapeutic application (among others, antithrombotic and anti-inflammatory effects) have been attributed to this compound [ 41 ]. Many years ago, fucoidan was described as a heparinase inhibitor in a tumor model [ 42 ], and this property has since been demonstrated in several other models [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

Regier

Drost

Rauen

et al. 2022

IJMS

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(1) Damage to the endothelial glycocalyx (eGC), a protective layer lining the endothelial luminal surface, is associated with chronic kidney disease (CKD), which leads to a worsening of cardiovascular outcomes in these patients. Currently, there are no targeted therapeutic approaches. Whether the dietary supplement EndocalyxTM (ECX) protects against endothelial damage caused by uremic toxins is unknown. (2) We addressed this question by performing atomic force microscopy measurements on living endothelial cells. We examined the effect of ECX on eGC thickness at baseline and with pooled serum from hemodialysis patients. ECX was also successfully administered in vivo in mice, in which eGC was assessed using perfused boundary region measurements by intravital microscopy of cremasteric vessels. (3) Both ECX and fucoidan significantly improved baseline eGC thickness. Our data indicate that these effects are dependent on ERK/MAPK and PI3K signaling. After incubation with eGC damaging serum from dialysis patients, ECX increased eGC height. Intravital microscopy in mice revealed a relevant increase in baseline eGC dimensions after feeding with ECX. (4) We identified a dietary supplement containing glycocalyx substrates and fucoidan as potential mediators of eGC preservation in vitro and in vivo. Our findings suggest that fucoidan may be an essential component responsible for protecting the eGC in acute settings. Moreover, ECX might contribute to both protection and rebuilding of the eGC in the context of CKD.

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Section: Discussionmentioning

confidence: 99%

“…Considering the lack of targeted therapy or prevention options, progress in this field is of great importance. In this regard, fucoidan has become of increasing interest in recent years [ 41 ]. Our present data suggest that part of its antiatherosclerotic effects might be due to the protection of the eGC.…”

Section: Discussionmentioning

confidence: 99%

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

Regier

Drost

Rauen

et al. 2022

IJMS

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“…Fucoidan and deep-sea water (DSW) are marine resources that have attracted much attention in recent years. Fucoidan is a unique polysaccharide in brown algae, and numerous studies have suggested that fucoidan exerts multiple biological effects, such as hypoglycemic, lipid-lowering, anticoagulation, antitumor, and antiviral activities [ 2 , 3 , 4 ]. DSW refers to seawater more than 200 m deep [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways

Peng

Zhou

et al. 2023

Pharmaceuticals

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Fucoidan and deep-sea water (DSW) are attractive marine resources for treating type 2 diabetes (T2DM). In this study, the regulation and mechanism associated with the co-administration of the two were first studied using T2DM rats, induced by a high fat diet (HFD) and streptozocin (STZ) injection. Results demonstrate that, compared to those with DSW or FPS alone, the orally administered combination of DSW and FPS (CDF), especially the high dose (H-CDF), could preferably inhibit weight loss, decrease levels of fasting blood glucose (FBG) and lipids, and improve hepatopancreatic pathology and the abnormal Akt/GSK-3β signaling pathway. The fecal metabolomics data show that H-CDF could regulate the abnormal levels of metabolites mainly through the regulation of linoleic acid (LA) metabolism, bile acid (BA) metabolism, and other related pathways. Moreover, H-CDF could adjust the diversity and richness of bacterial flora and enrich bacterial groups, such as Lactobacillaceae and Ruminococcaceae UCG-014. In addition, Spearman correlation analysis illustrated that the interaction between the gut microbiota and BAs plays an essential role in the action of H-CDF. In the ileum, H-CDF was verified to inhibit activation of the farnesoid X receptor (FXR)–fibroblast growth factor 15 (FGF15) pathway, which is regulated by the microbiota–BA–axis. In conclusion, H-CDF enriched Lactobacillaceae and Ruminococcaceae UCG-014, thereby changing BA metabolism, linoleic acid metabolism, and other related pathways, as well as enhancing insulin sensitivity and improving glucose and lipid metabolism.

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“… 40 , 41 These substances were formed via α-1,3-glycosidic, α-1,4-glycosidic, β-1,3-glycosidic, and β-1,4-glycosidic bonds and have great potential in applications in tissue engineering, biomedicine, drug delivery, food, and so on. 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 …”

Section: Introductionmentioning

confidence: 99%

“… 26 Cardiovascular diseases Wang et al. 27 Anticoagulant Shanthi et al. 28 Carrageenan sulfated D-galactose α-1, 4-GB β-1, 3-GB Tissue engineering Jafari et al.…”

Section: Introductionmentioning

confidence: 99%

Exploring carbohydrate extraction from biomass using deep eutectic solvents: Factors and mechanisms

Liu,

Gao,

Chen

et al. 2023

iScience

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Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Cited by 20 publications

References 104 publications

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways

Exploring carbohydrate extraction from biomass using deep eutectic solvents: Factors and mechanisms

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