Application of functional near-infrared spectroscopy to explore the neural mechanism of transcranial direct current stimulation for post-stroke depression

Li, Hongyu; Zhu, Ning; Klomparens, Eric A; Xu, Shunqing; Man, Weitao; Wang, Qiang; Wang, Jing; Song, Lina

doi:10.1080/01616412.2019.1612539

Cited by 14 publications

(11 citation statements)

References 21 publications

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“…Based on the analysis results, the minimum duration for effective stimulation of tDCS in the desired area was proposed, and a time point for effective rehabilitation exercise was suggested. Using the results of this study, it is possible to improve the treatment effects for ischemic stroke survivors [ 48 , 49 ] poststroke depression [ 50 ], schizophrenia [ 51 ], nicotine dependence [ 52 ], tinnitus [ 53 ], and various motor functions which are currently being attempted by combining tDCS and fNIRS. In addition, combining HD-tDCS, which provides focused stimulation, is expected to be utilized for more neurologic diseases.…”

Section: Discussionmentioning

confidence: 99%

Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

Lee

Kim

et al. 2022

JPM

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In this study, the effective application of high-definition transcranial direct current stimulation (HD-tDCS) based on the whole brain hemodynamic response in stroke patients was investigated using functional near-infrared spectroscopy (fNIRS). The intrahemispheric and interhemispheric synchronization and cortical activity based on the time during 1 mA HD-tDCS were examined in 26 chronic cerebrovascular disease patients. At the beginning of HD-tDCS, the synchronization and brain activity in the whole brain increased rapidly and decreased after 5 min. In the middle of tDCS, the synchronization began to increase again, and strong synchronic connections were formed around the desired stimulation area. After tDCS, strong cortical activation was observed in the stimulation area, indicating that the baseline of the oxyhemoglobin (HbO) signal increased in the desired stimulation area. Therefore, the results of this study indicate that HD-tDCS can be applied efficiently to enhance the effect of tDCS. This stimulation method with tDCS can be explored clinically for more neurorehabilitation of patients with degenerative brain diseases.

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Section: Discussionmentioning

confidence: 99%

Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

Lee

Kim

et al. 2022

JPM

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“…But the meta-regression may only disclose a 'tendency' and does not mean that NINCEN was ineffective in the elderly. Several studies in the elderly and in patients post-stroke have revealed NINCEN to be beneficial for both emotional and cognitive function (Li et al, 2019a;Lu et al, 2020;Valiengo et al, 2017;Wong et al, 2019). Some analyses on depression and sleep disturbance did not pass the leave-one-out sensitivity analysis, which means that the significance levels of these analyses would change when one included study was removed.…”

Section: Discussionmentioning

confidence: 99%

“…But the meta-regression may only disclose a ‘tendency’ and does not mean that NINCEN was ineffective in the elderly. Several studies in the elderly and in patients post-stroke have revealed NINCEN to be beneficial for both emotional and cognitive function (Li et al, 2019 a ; Lu et al, 2020; Valiengo et al, 2017; Wong et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of non-invasive, non-convulsive electrical neuromodulation on depression, anxiety and sleep disturbance: a systematic review and meta-analysis

Cheng

Kuo

et al. 2022

Psychol. Med.

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The effects of non-invasive, non-convulsive electrical neuromodulation (NINCEN) on depression, anxiety and sleep disturbance are inconsistent in different studies. Previous meta-analyses on transcranial direct current stimulation (tDCS) and cerebral electrotherapy stimulation (CES) suggested that these methods are effective on depression. However, not all types of NINECN were included; results on anxiety and sleep disturbance were lacking and the influence of different populations and treatment parameters was not completely analyzed. We searched PubMed, Embase, PsycInfo, PsycArticles and CINAHL before March 2021 and included published randomized clinical trials of all types of NINCEN for symptoms of depression, anxiety and sleep in clinical and non-clinical populations. Data were pooled using a random-effects model. The main outcome was change in the severity of depressive symptoms after NINCEN treatment. A total of 58 studies on NINCEN were included in the meta-analysis. Active tDCS showed a significant effect on depressive symptoms (Hedges' g = 0.544), anxiety (Hedges' g = 0.667) and response rate (odds ratio = 1.9594) compared to sham control. CES also had a significant effect on depression (Hedges' g = 0.654) and anxiety (Hedges' g = 0.711). For all types of NINCEN, active stimulation was significantly effective on depression, anxiety, sleep efficiency, sleep latency, total sleep time, etc. Our results showed that tDCS has significant effects on both depression and anxiety and that these effects are robust for different populations and treatment parameters. The rational expectation of the tDCS effect is ‘response’ rather than ‘remission’. CES also is effective for depression and anxiety, especially in patients with disorders of low severity.

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“…In the fNIRS study (Li et al, 2019), 26 patients with poststroke depression received tDCS for 20 min with a 2-mA current on the left DLPFC and a return electrode at the right DLPFC. Each subject underwent five stimulation sessions weekly for 4 weeks.…”

Section: Depressive Disordermentioning

confidence: 99%

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

2021

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BackgroundBrain disorders are gradually becoming the leading cause of death worldwide. However, the lack of knowledge of brain disease’s underlying mechanisms and ineffective neuropharmacological therapy have led to further exploration of optimal treatments and brain monitoring techniques.ObjectiveThis study aims to review the current state of brain disorders, which utilize transcranial electrical stimulation (tES) and daily usable noninvasive neuroimaging techniques. Furthermore, the second goal of this study is to highlight available gaps and provide a comprehensive guideline for further investigation.MethodA systematic search was conducted of the PubMed and Web of Science databases from January 2000 to October 2020 using relevant keywords. Electroencephalography (EEG) and functional near-infrared spectroscopy were selected as noninvasive neuroimaging modalities. Nine brain disorders were investigated in this study, including Alzheimer’s disease, depression, autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, Parkinson’s disease, stroke, schizophrenia, and traumatic brain injury.ResultsSixty-seven studies (1,385 participants) were included for quantitative analysis. Most of the articles (82.6%) employed transcranial direct current stimulation as an intervention method with modulation parameters of 1 mA intensity (47.2%) for 16–20 min (69.0%) duration of stimulation in a single session (36.8%). The frontal cortex (46.4%) and the cerebral cortex (47.8%) were used as a neuroimaging modality, with the power spectrum (45.7%) commonly extracted as a quantitative EEG feature.ConclusionAn appropriate stimulation protocol applying tES as a therapy could be an effective treatment for cognitive and neurological brain disorders. However, the optimal tES criteria have not been defined; they vary across persons and disease types. Therefore, future work needs to investigate a closed-loop tES with monitoring by neuroimaging techniques to achieve personalized therapy for brain disorders.

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Application of functional near-infrared spectroscopy to explore the neural mechanism of transcranial direct current stimulation for post-stroke depression

Cited by 14 publications

References 21 publications

Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

The efficacy of non-invasive, non-convulsive electrical neuromodulation on depression, anxiety and sleep disturbance: a systematic review and meta-analysis

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

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