Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Kim, Hak Yeong; Seo, Kain; Jeon, Hong Jin; Lee, Unjoo; Lee, Hyosang

doi:10.14348/molcells.2017.0153

Cited by 75 publications

(54 citation statements)

References 148 publications

(160 reference statements)

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“…Thus, prefrontal activity markers during chewing and somatic state examinations, such as SCL-90-R, may be useful in clinical settings to analyze the neuro-pathological background in patients complaining of persistent OD. This suggestion is in line with previous research results showing that fNIRS is a functional imaging method that relies on the principal of neurovascular couplings and applicable for evaluation of psychiatric state using prefrontal cortex blood flow in patients with psychiatric disorders [22,23,[58][59][60][61][62][63].…”

Section: Discussionsupporting

confidence: 91%

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

et al. 2018

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Objectives Neuropsychological associations can be considerable in occlusal dysesthesia (OD) patients who routinely complain of persistent occlusal discomfort, and somatization effects in the superior medial prefrontal cortex and the temporal and parietal regions are also present. However, the relationship between physical activity, i.e., chewing, prefrontal cognitive demand, and psychiatric states in OD patients remains unclear. We investigated this relationship in this study. Materials and methods OD patients (n = 15) and healthy control (n = 15; HC) subjects were enrolled in this study. Occlusal contact, chewing activities of the masticatory muscles, prefrontal activities, and psychiatric states such as depression and somatization, of the participants were evaluated. Functional near-infrared spectroscopy was used to determine prefrontal hemodynamics and the Symptom Checklist-90-R was used to score the psychiatric states. Results We observed a significant association between prefrontal deactivation during chewing and somatization subscales in OD patients. Further, there were no significant differences with regard to the occlusal state and chewing physical activities between the OD patients and HC subjects. Conclusions Chewing-related prefrontal deactivation may be associated with somatization severity in OD patients. Clinical relevance fNIRS is a functional imaging method that uses the principal of neuro-vascular couplings. It is applicable for evaluation of psychiatric state based on prefrontal cortex blood flow in patients with psychiatric disorders.

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Section: Discussionsupporting

confidence: 91%

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

et al. 2018

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“…Functional Near-Infrared-Spectroscopy (fNIRS) equipment has become commercially available and widely used in clinical practice such as diagnosis in psychiatry, neurosurgery or pediatrics (Kim et al, 2017). The continuous-wave near-infrared spectroscopy has made it possible to measure hemodynamic change in the living tissue, or more precisely the product of change in hemoglobin concentration in living tissue and the mean optical path length.…”

Section: Introductionmentioning

confidence: 99%

Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy

Klempíř

Krupička

Mehnert

et al. 2019

JAB

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Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.

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“…1 Several noninvasive methods have been introduced in recent decades for measuring neuronal activity in the brain. 2 Neurophysiological techniques such as electroencephalography, magnetoencephalography, and event-related potentials offer the ability to measure overall changes in the electromagnetic field with an excellent time resolution, but these methods have poor spatial resolution. On the other hand, brain imaging techniques such as positron-emission tomography (PET) and functional magnetic resonance imaging (fMRI) have greatly increased our knowledge about neural circuitry.…”

Section: Introductionmentioning

confidence: 99%

Application of near-infrared spectroscopy in clinical neurology

Kim

Bae

2018

Ann Clin Neurophysiol

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Near-infrared spectroscopy (NIRS) monitoring has been used mainly to detect reduced perfusion of the brain during orthostatic stress in order to assess orthostatic intolerance (OI). Many studies have investigated the use of NIRS to reveal the pathophysiology of patients with OI. Research using NIRS in other neurological diseases (e.g., stroke, epilepsy, and migraine) is continuing. NIRS may play an important role in monitoring the regional distribution of the hemodynamic flow in real time and thereby reveal the underlying pathophysiology and facilitate the management of not only patients with OI symptoms but also those with various neurological diseases.Key words: Orthostatic intolerance; Near-infrared spectroscopy; Clinical neurology INTRODUCTIONMany studies have investigated the hemodynamics and functions of the brain in various fields.1 Several noninvasive methods have been introduced in recent decades for measuring neuronal activity in the brain. 2 Neurophysiological techniques such as electroencephalography, magnetoencephalography, and event-related potentials offer the ability to measure overall changes in the electromagnetic field with an excellent time resolution, but these methods have poor spatial resolution. On the other hand, brain imaging techniques such as positron-emission tomography (PET) and functional magnetic resonance imaging (fMRI) have greatly increased our knowledge about neural circuitry. However, PET is highly sensitive to motion artifacts, confines the patient, and involves the injection of radioactive materials. Although fMRI is noninvasive and has excellent spatial resolution, it is expensive, highly sensitive to motion artifacts, and difficult to integrate with other imaging modalities. 3,4 Near-infrared spectroscopy (NIRS) was introduced as a new neuroimaging modality for Principle of NIRSNIRS is a noninvasive optical imaging tool for observing changes in the hemodynamics in the prefrontal area that is based on measuring the concentrations of HbO and HbR in the blood. Since Franz Jöbsis first studied the oxygenation of living tissues, NIRS has been extensively applied in imaging studies of brain activation. 6 The physiological activation of neurons leads to an imbalance between oxygen supply and utilization, increasing the concentration of HbO and decreasing the concentration of HbR. Most tissues are relatively transparent to light in the near-infrared range from 700 to 900 nm, and photons interact with tissues via absorption and scattering. This means that near-infrared light is less absorbed and scattered by tissue than is light at other wavelengths. 7 This range of wavelengths is often called an optical window since the light can easily pass through most tissues; however, it is reflected by HbO and HbR, and hence the absorption and scattering of light used for NIRS can provide information relevant to neural activity. 8 This light penetrates several centimeters through tissue and can still be detected (Fig. 1). The NIRS system consists of a light source and a photodetector. The l...

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Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Cited by 75 publications

References 148 publications

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy

Application of near-infrared spectroscopy in clinical neurology

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