Football is one of the sports that is loved by people all over the world. Its sales ability in the league should not be underestimated. Moreover, football has been developed in our country since ancient times and has a huge fan base, and fans are the main target of football league sales. Predicting the sales effect of the football league is helpful for the seller to formulate a suitable sales strategy and avoid the problem of product surplus. This article mainly introduces the prediction research of football league sales effect based on BP neural network, and intends to provide ideas and methods for predicting the sales effect of football league. This paper puts forward the basic method of the sales effect prediction of the football league and the BP neural network football league sales effect prediction method to analyze and predict the sales effect of the football league. In addition, the steps of establishing BP neural network design, building BP neural network football league sales effect prediction model and applying BP neural network football league sales effect prediction model are also proposed. The experimental results of this article show that the difference between the fitting part of the neural network model and the real value of the football league sales effect sample data is in the range of , the error percentage difference is small, and the prediction results are valid。